Notebook for Clinical processing¶
Sumarise clinical features & case mutations / molecular phenotypes.¶
Here we want to sumarise some of the major clinical features.
Demographics¶
- Race demographics (ethnicity_self_identified)
- Age (age) --> separate into young (< 50) mid (50 - 70), old (> 70)?
- BMI (BMI) --> separate into underweight (< 19) normal (19 - 25), pre-obese (26-30), obsesity class 1 (30 - 35), obesisty class 2 (35 - 40), obesity class 3) (41 - 49
- tumour stage (tumor_stage_pathological)
- tumour size (tumor_size_in_cm)
- white cell count (white_cell_count)
- vital status (vital_status_at_12months_follow_up)
Mutations¶
- MTOR (5)
- TP53 (6)
- SETD2 (11)
- BAP1 (14)
- KDM5C (16)
- PBRM1 (37)
- VHL (73)
- TTN (21)
- CUBN (10)
- BRCA2 (3)
Molecular phenotypes¶
Here we have:
- CIMP+ or CIMP-
- Stable or unstable.
Clinical information¶
Downloaded information from (metadata files). https://cptac-data-portal.georgetown.edu/study-summary/S050
Couldn’t find matching patient names between the clinical attributes in the protein data so had to down load the data from: https://cptac-data-portal.georgetown.edu/study-summary/S044
In [1]:
import pandas as pd
base_dir = '../data/'
data_dir = f'{base_dir}raw_downloads/CPTAC/'
output_dir = f'{base_dir}sircle/F1_DE_input_TvN/'
# First we need to get demographic info from the clinical DF
clin_df = pd.read_csv(f'{data_dir}Patient_Clinical_Attributes.csv')
clin_mod_df = pd.DataFrame()
case_id = 'case_id'
gender = 'gender'
age = 'age'
age_grp = 'AgeGrouped'
race_grp = 'RaceGrouped'
bmi = 'BMI'
bmi_grp = 'BMIGrouped'
race = 'ethnicity_self_identified'
t_stage = 'tumor_stage_pathological'
t_size = 'tumor_size_in_cm'
cell_count = 'white_cell_count'
status = 'vital_status_at_12months_follow_up'
# Add in the base info to the our version of the clin df
clin_mod_df[case_id] = clin_df[case_id].values
clin_mod_df[gender] = clin_df[gender].values
clin_mod_df['TumorStage'] = clin_df[t_stage].values
age_grps = []
for a in clin_df[age]:
if a == '>=90':
age_grps.append('old')
elif int(a) < 42:
age_grps.append('young')
elif int(a) < 58:
age_grps.append('middle')
elif int(a) < 90:
age_grps.append('old')
else:
print(a)
bmi_grps = []
for a in clin_df[bmi]:
if int(a) < 19:
bmi_grps.append('underweight')
elif int(a) < 25:
bmi_grps.append('normal')
elif int(a) < 30:
bmi_grps.append('pre-obese')
elif int(a) < 35:
bmi_grps.append('obese-1')
elif int(a) < 40:
bmi_grps.append('obese-2')
elif int(a) < 70:
bmi_grps.append('obese-3')
else:
print('BMI', a)
bmi_grps = []
for a in clin_df[bmi]:
if int(a) < 19:
bmi_grps.append('normal')
elif int(a) < 25:
bmi_grps.append('normal')
elif int(a) < 30:
bmi_grps.append('between')
elif int(a) < 35:
bmi_grps.append('between')
elif int(a) < 40:
bmi_grps.append('obese')
elif int(a) < 70:
bmi_grps.append('obese')
else:
print('BMI', a)
clin_mod_df[age_grp] = age_grps
clin_mod_df[bmi_grp] = bmi_grps
# Make the race groups simplified
race_grp = 'RaceGrouped'
race_grps = []
for r in clin_df[race]:
if r == 'Caucasian' or r == 'White' or r == 'American':
race_grps.append('White')
elif r == 'Slavonic':
race_grps.append('Slavonic')
elif r == 'Medical record does not state' or r == 'Patient not interviewed':
race_grps.append('NA')
elif r == 'Hispanic':
race_grps.append('Hispanic')
else:
race_grps.append('Asian')
print(r)
clin_mod_df[race_grp] = race_grps
# Print out the different groups
demo_cols = [age_grp, bmi_grp, race_grp, gender]
for d in demo_cols:
print(clin_mod_df[d].value_counts())
Asian Vietnam Asian Asian Indian old 66 middle 35 young 9 Name: AgeGrouped, dtype: int64 between 56 obese 33 normal 21 Name: BMIGrouped, dtype: int64 White 78 NA 12 Slavonic 11 Asian 5 Hispanic 4 Name: RaceGrouped, dtype: int64 Male 80 Female 30 Name: gender, dtype: int64
Mutations¶
First we need to download all the mutations and make a dataframe based on these (only needs to be done once).
Then we want to look at all the different mutations and annote these to cases.
In [2]:
"""
We only want to do this once I keep it off by default :)
"""
# Download mutation data
# Here we want to download the mutation files
from scidat.download import Download
from sciutil import SciUtil
supp_dir = f'{base_dir}raw_downloads/supps/' # Where you need to put the GDC client
u = SciUtil()
case_ids = list(set(clin_mod_df[case_id].values))
download_mutation = False
if download_mutation:
download = Download(f'{data_dir}RNA_clinical.csv',
f'{data_dir}mutations/',
f'{data_dir}mutations/',
f'{supp_dir}gdc-client',
max_cnt=1)
download.download_data_using_api(case_ids, 'mutation')
else:
u.dp(["You said you already have your mutations downloaded, if this isn't the case you'll need to do this!"])
-------------------------------------------------------------------------------- You said you already have your mutations downloaded, if this isn't the case you'll need to do this! --------------------------------------------------------------------------------
In [3]:
# Set up the mutation stuff (already downloaded mutation info in the processing dir)
from scidat.api import API, APIException
tcga_data_dir = f'{base_dir}raw_downloads/TCGA/'
gdc_client = f'{tcga_data_dir}./gdc-client'
sample_file = f'{tcga_data_dir}gdc_sample_sheet.2021-05-03.tsv'
manifest_file = f'{tcga_data_dir}gdc_manifest_20210503_065756.txt'
annotation_file = f'{supp_dir}hsapiens_gene_ensembl-GRCh38.p13.csv'
clinical_file = f'{tcga_data_dir}clinical.cart.2021-05-03/clinical.tsv'
api = API(manifest_file, gdc_client, clinical_file, sample_file, data_dir, data_dir, annotation_file,
max_cnt=10, requires_lst=['counts'])
mutation_dir = f'{data_dir}mutations/'
api.build_mutation_df(mutation_dir)
# Now we want to build a dictionary with mutations and cases.
filter_col = 'ssm.consequence.0.transcript.gene.symbol'
genes_with_mutations = api.get_mutation_values_on_filter('ssm.consequence.0.transcript.gene.symbol', [''], 'ssm.consequence.0.transcript.gene.symbol')
# Now for each gene we want to count the patients with mutations
cases_w_mutations = {}
for g in genes_with_mutations:
cases = api.get_mutation_values_on_filter('case_id', [g], filter_col, exact=True)
cases_w_mutations[g] = cases
# Sort keys by the genes with most mutations
sorted_genes_w_mutations = sorted(cases_w_mutations, key=lambda k: len(cases_w_mutations[k]), reverse=True)
# Print these out!
for g in sorted_genes_w_mutations:
print(g, len(cases_w_mutations[g]))
VHL 73 PBRM1 37 TTN 21 KDM5C 16 BAP1 14 MUC16 12 CSMD3 12 SETD2 11 USH2A 10 CUBN 10 MALAT1 8 TNRC18 8 BIRC6 7 RELN 7 SYNE1 7 MACF1 7 LRP2 7 CCDC168 6 RSF1 6 PCLO 6 TP53 6 DST 6 KIF1B 6 MYO16 5 OPTN 5 PKHD1 5 ARHGAP32 5 SVEP1 5 NEB 5 SYNE2 5 HSPA8 5 XIRP2 5 HECW1 5 TNKS 5 PCDHB6 5 PIKFYVE 5 PCDH15 5 CSMD2 5 ADAMTS20 5 PITPNM2 5 PTEN 5 MUC17 5 GOLGB1 5 YLPM1 5 RYR2 5 FAT2 5 MTOR 5 FCGBP 5 OBSCN 5 KMT2C 5 HMCN1 5 VAPB 5 ANK3 5 RPRD2 5 FAT1 5 EXPH5 4 SMG1 4 SYCP2L 4 PCDH20 4 NAV3 4 ITGA3 4 USP34 4 ABCC12 4 KIAA0100 4 NELL2 4 ZNF91 4 GLI2 4 DYNC1H1 4 UNC13B 4 PPWD1 4 KCNH5 4 ZACN 4 TTC3 4 LAMB4 4 SLC4A4 4 CACNA1F 4 CACNA1H 4 HECTD4 4 KCNA4 4 DGKZ 4 CHD3 4 IGKC 4 LAMA2 4 PHTF1 4 MON2 4 FSIP2 4 RNF213 4 RPS6KC1 4 FAM179B 4 AHCTF1 4 PTPRK 4 TERT 4 COL22A1 4 PCDH7 4 TMEM108 4 KDM2B 4 MYO15A 4 VPS13D 4 ANKRD26 4 NLRP12 4 TNC 4 RALGAPB 4 NOTCH3 4 AUTS2 4 POM121 4 SPEG 4 CAND1 4 SF3B1 4 EPHB2 4 ACACA 4 MALRD1 4 WWC3 4 CHD9 4 MAPT 4 GREB1 4 CHUK 4 KIAA1109 4 DNAH3 4 ZNF292 4 RAD54L 4 AKAP13 4 ASTN1 4 CCIN 4 FAT3 4 ACBD5 4 LIF 4 DNAH5 4 CUL9 4 KIAA1755 4 PKD1 4 COLEC11 4 UNC80 4 PIEZO1 4 CHRNA4 4 DNAH17 4 MAP1A 4 SORBS2 4 CHD6 4 EPB42 3 BRCA2 3 SYMPK 3 HDHD3 3 ADAMTS12 3 NSD1 3 MAGI3 3 ATP7B 3 KIAA0430 3 CUX1 3 ADGRB2 3 ATXN2L 3 NALCN 3 ZSWIM8 3 NR2F2 3 CHD2 3 CTSA 3 ILF3 3 DNAH2 3 KIAA0319L 3 PNPLA3 3 STIP1 3 COL24A1 3 IL12A 3 PACS2 3 ARHGEF12 3 ROCK2 3 NRXN1 3 MAST1 3 SLITRK6 3 FOXP2 3 ADGRF5 3 BRCA1 3 NRK 3 MDH2 3 BRINP2 3 URGCP 3 DOCK7 3 FAM21A 3 PCNT 3 MYH3 3 TMCO1 3 WNK3 3 MUC4 3 MUC6 3 FAT4 3 LRRC61 3 PCDHB3 3 TACC2 3 PTPRF 3 TBC1D9 3 CDK13 3 MROH2B 3 MAGEL2 3 FAM214A 3 WT1 3 GRAMD1A 3 RHBDL3 3 DLG5 3 TP53BP1 3 CDH8 3 CCER1 3 EP400 3 XBP1 3 LMO7 3 PKP3 3 ZNF638 3 SEZ6L2 3 KCNG1 3 NUP98 3 NACA 3 KCP 3 NIPBL 3 CELSR1 3 NPSR1 3 NCKAP5 3 WDFY4 3 ABCB4 3 SLC11A2 3 MDGA1 3 NUGGC 3 CHD8 3 AASDH 3 KCTD15 3 NEK1 3 DSCAM 3 APOB 3 WDFY3 3 ZNF729 3 KMT2D 3 TSC22D1 3 TRPC7 3 DMD 3 PKD1L1 3 SORL1 3 MPRIP 3 PRX 3 ZMYND8 3 WDR87 3 CDH23 3 RGS22 3 MUC5AC 3 PIEZO2 3 LRRC4B 3 SH2B1 3 C1orf168 3 ARFGEF2 3 CLMN 3 GTF3C1 3 MYO9A 3 PRPF8 3 TTLL10 3 THBS1 3 CFAP74 3 NUP188 3 PIK3CD 3 GRIN3A 3 LRP1 3 RANBP2 3 PIK3R1 3 RAB11FIP1 3 FLYWCH1 3 VPS13A 3 IQSEC2 3 C3 3 SAMD14 3 ZNF317 3 INPP5B 3 UGT1A7 3 DSC3 3 LMTK2 3 SMARCA4 3 ZBED6 3 MUC5B 3 MPP4 3 PLXND1 3 COL4A2 3 CRNKL1 3 AASS 3 MAST4 3 AHNAK 3 PTPRC 3 PIGQ 3 ASTN2 3 DCHS1 3 SLC7A13 3 LYST 3 SPHKAP 3 LILRB1 3 LINC00273 3 ACSL5 3 SNX5 3 PADI1 3 FGD2 3 PIK3CA 3 PHF20 3 LRP1B 3 GRM8 3 IRF2BP2 3 TPM1 3 RAPGEF2 3 PCNXL4 3 HCN4 3 SYTL2 3 ADGRB3 3 LRRK2 3 ADAMTS1 3 ADCY8 3 CSMD1 3 TRPM8 3 MROH9 3 SLC27A1 3 CLSTN3 3 FANCC 3 CFAP43 3 NRBP1 3 SPG11 3 NR2F1 3 KDM6B 3 KLF6 3 SAP30BP 3 TGM5 3 REST 3 IGSF9B 3 GGT7 3 GVINP1 3 COL18A1 3 COL28A1 3 CLPB 3 MAP2K3 3 TCF4 3 NID2 3 KIAA1671 3 ZNF407 3 SI 3 MYO3A 3 GOLGA6L2 3 GLS 3 GLTSCR2 3 NCAPD3 3 ADCY9 3 DUSP22 3 TRRAP 3 ZSCAN29 3 COL5A1 3 ERCC5 3 SON 3 HRNR 3 IL4R 3 TMEM151B 3 SPATA2L 3 EIF2AK2 3 ARID1B 3 DNAH11 3 DMXL1 3 DYSF 3 CEP250 3 SEC16A 3 SMTNL2 3 PDE2A 3 WWC1 3 MAP3K5 3 SPEF2 3 TBR1 3 SPNS1 3 ZNF831 3 SGSH 3 ITPRIPL2 3 PKD1L2 3 DNAH9 3 ARHGEF19 3 RAB36 3 PCDHGA4 3 PTPRQ 3 RBMXL3 3 TULP4 3 WDR66 3 MATR3 3 ZFHX3 3 RYR1 3 TTC6 3 TMEM87A 3 CEP41 3 INSR 3 SPTA1 3 RIMS1 3 SIPA1L3 3 ALMS1 3 RASA1 3 ADCY4 3 ROBO3 3 GYS1 3 MYH13 3 TNKS2 3 ACSS2 3 FMR1 3 CCDC18 3 SBNO1 3 CFAP54 3 WDR33 3 RGPD3 2 TRIP12 2 DVL2 2 TDRD5 2 ZNF880 2 ELF3 2 HSD11B1L 2 GPR89A 2 WDR81 2 STAG1 2 AATK 2 ZC3H12C 2 ADCY6 2 RC3H1 2 MANBA 2 L3MBTL1 2 ILF2 2 RP11-252A24.2 2 SEPT14 2 AP2A2 2 TMEM63C 2 CD81 2 SUPT5H 2 USP31 2 ZNF512B 2 COG6 2 NLE1 2 DCAF17 2 CENPE 2 SMC4 2 GPI 2 NTRK1 2 SETX 2 FLII 2 QSER1 2 SOHLH1 2 CCDC42 2 TIAL1 2 BRAT1 2 RXRA 2 TRIM42 2 TRDN 2 FHOD3 2 TSHZ1 2 SCYL2 2 OXR1 2 FSD2 2 SIPA1L2 2 DUSP2 2 TUBGCP3 2 BMS1 2 ERCC6-PGBD3 2 ERGIC3 2 YTHDC2 2 CEP295 2 CDC42EP4 2 OR2M5 2 DMGDH 2 ADGRG4 2 CEP152 2 C12orf40 2 AP4E1 2 TRAF3IP1 2 SCN9A 2 MAP3K19 2 PRDM14 2 RIF1 2 EPRS 2 OR52H1 2 ITPKB 2 ST6GAL2 2 BACH1 2 SIRT1 2 ABCB11 2 NECAB2 2 LEKR1 2 DONSON 2 NKTR 2 POM121C 2 TRMT5 2 DYRK4 2 HMCN2 2 LIMA1 2 MYOCD 2 FBLN1 2 SLIT2 2 ELOVL4 2 NCCRP1 2 SACS 2 FDPS 2 SCNN1A 2 MAST3 2 PCDHGC4 2 TNNC2 2 BCR 2 MAN2B1 2 DTNA 2 PNP 2 ACSF3 2 ATAD2 2 XIST 2 WDR41 2 CAMSAP3 2 MAGEB10 2 SPEM1 2 FYCO1 2 ZNF420 2 GNPTAB 2 BRD2 2 MVD 2 PATL1 2 PADI6 2 RAPGEF1 2 ATP6V1B2 2 FAM117B 2 ZNF614 2 UBASH3B 2 TCF7L2 2 USP4 2 TENM3 2 CTNNA1 2 F13A1 2 SLC22A12 2 ATR 2 COL27A1 2 GABRG3 2 LENG8 2 IFIH1 2 NBEA 2 ZNF419 2 GLIS3 2 TESK1 2 TM9SF2 2 LRRC49 2 CASZ1 2 NES 2 ZNF790 2 IFT172 2 NFXL1 2 VPS13B 2 AADACL3 2 NLRX1 2 RNFT1 2 GNB2L1 2 USP24 2 SUN2 2 HEPACAM 2 TMIGD2 2 DHX30 2 DLX6 2 TMEM132C 2 STAB1 2 FOXN1 2 MICAL2 2 ANKRD30A 2 BCL2L13 2 SUZ12 2 UBBP4 2 ABCA7 2 COL11A1 2 PRAMEF2 2 SLC12A2 2 CNTNAP1 2 MYCBP 2 PDE4DIP 2 PLXNA4 2 TENM4 2 ZXDA 2 MYLK 2 IQGAP3 2 ZNF207 2 FBN3 2 GNS 2 COL6A2 2 KANSL3 2 SBF1 2 PTPRD 2 RBFOX1 2 ZNF644 2 ITGAL 2 MTHFS 2 STK32C 2 CREBBP 2 CADPS2 2 OR1C1 2 MPV17L2 2 MTR 2 TUBB3 2 TTC23 2 TRAPPC13 2 PRSS12 2 KLHL30 2 DHX29 2 ZDBF2 2 RPTOR 2 OR2V1 2 ZCCHC14 2 APOH 2 FTL 2 TROVE2 2 TBX6 2 IFIT1B 2 TFEC 2 CCDC9 2 SEMA7A 2 MTUS1 2 SCAPER 2 ATP2B1 2 PHLDB1 2 ANKRD36C 2 EFTUD2 2 CELSR3 2 P3H1 2 FGD5 2 PREX2 2 NUP160 2 MTMR3 2 TUBAL3 2 TENM2 2 DOT1L 2 LRRC70 2 CACNA1S 2 IMPDH1 2 KIF22 2 PREX1 2 TSHZ2 2 MMP2 2 MGA 2 CPA5 2 ADAMTS10 2 CCDC74B 2 LRIG2 2 WARS 2 CKAP2 2 EIF2B2 2 KIAA1107 2 AMBRA1 2 BPIFB6 2 MCF2L 2 BTBD1 2 NAPB 2 RABEP1 2 SEPT5 2 SH3RF3 2 FAM179A 2 KCNJ3 2 PRDM15 2 CAPN2 2 AFMID 2 ZNF544 2 KNDC1 2 TALDO1 2 SUFU 2 KIF20B 2 BRD7 2 TARS 2 CHIT1 2 ITIH6 2 ZNF219 2 HADHA 2 SETD1A 2 HCRTR1 2 SYNGAP1 2 MLLT4 2 BRINP1 2 CUX2 2 CELF2 2 LRRFIP1 2 PCBP1 2 FASTKD1 2 MEFV 2 AIM1L 2 MED1 2 ZNF229 2 ANKLE2 2 GAB4 2 ACSL1 2 CDK11B 2 EHHADH 2 COL6A5 2 HOXB4 2 ZXDC 2 WHAMM 2 KLHL17 2 CYFIP1 2 RTN1 2 EXOC2 2 ZNF319 2 HDAC8 2 PELI2 2 SALL3 2 CEP95 2 RPP40 2 TXNIP 2 SOD1 2 ARHGEF3 2 GABRE 2 KANSL1L 2 ATE1 2 GOLGA8J 2 COLQ 2 WIZ 2 DNAH14 2 ZNF649 2 DCC 2 ZNF267 2 DLGAP2 2 DMBT1 2 RANBP3L 2 HIVEP1 2 PPP1R3B 2 WNK2 2 ZFP36 2 DUSP9 2 CYP2S1 2 PKP4 2 BCCIP 2 TPP1 2 F13B 2 PLA2G7 2 AIP 2 PLAUR 2 PDK2 2 ERBB2IP 2 PBX3 2 CTC-236F12.4 2 CPN1 2 ZNF568 2 MYBL1 2 SLC3A1 2 NFKBIA 2 GTF2H1 2 PRDM2 2 MED15 2 RCOR3 2 ERN1 2 XRN1 2 EPS8 2 LRRC15 2 ZNF616 2 DROSHA 2 LRRC8A 2 PLA2G4A 2 CLUH 2 AOC1 2 TGFBR2 2 BHMG1 2 CLCN5 2 GANC 2 SRCAP 2 ABL1 2 ZDHHC13 2 PASD1 2 ZNF19 2 MLIP 2 ALOX12B 2 ZSCAN23 2 RIPPLY1 2 BPTF 2 CHST4 2 MPND 2 PTPRB 2 DEK 2 CNOT1 2 NET1 2 CPA2 2 RLF 2 MYH6 2 PRPF4B 2 NFX1 2 EIF4ENIF1 2 TRAF3IP2 2 CLPTM1L 2 FRY 2 PCDHAC1 2 KCNMA1 2 CYP11B2 2 RTCB 2 NPHP3 2 AAK1 2 ALDH1L1 2 B3GALT1 2 MUC20 2 SLC19A1 2 NEGR1 2 FRYL 2 ATIC 2 NINL 2 CLCN1 2 RP11-683L23.1 2 SLC5A1 2 ARHGAP21 2 FSTL4 2 LNPEP 2 C2CD3 2 ABCA13 2 DRICH1 2 ZNF516 2 TP53I11 2 HELB 2 KCTD9 2 CNTNAP2 2 PFKFB1 2 MFSD2A 2 CPAMD8 2 NDRG1 2 MMS19 2 CYP3A5 2 FAM49B 2 PIK3R6 2 RNF43 2 MAN2B2 2 UFSP2 2 CDH22 2 DMXL2 2 TFAP2D 2 PARP6 2 SCAF4 2 SEPT1 2 TMEM132D 2 F12 2 SKOR1 2 STXBP6 2 MEGF10 2 TEX15 2 ZFR 2 ZNF735 2 IQUB 2 TAOK1 2 IFIT5 2 TNFRSF13B 2 CLCN7 2 MAN1C1 2 C9orf171 2 SLIT1 2 MAPK7 2 KEL 2 SDK2 2 ALK 2 WDR72 2 PCDHGC3 2 ACACB 2 KAT6A 2 METTL12 2 ZNF470 2 FOXK2 2 PXDN 2 TEX13A 2 SRGAP3 2 SLCO1C1 2 ZNF239 2 C5orf42 2 AFF4 2 STEAP4 2 GPHN 2 GLRB 2 TRPM3 2 ST6GALNAC2 2 VCAM1 2 MYO1E 2 PCDHGB6 2 ZNF852 2 BCOR 2 FAM53C 2 KIAA2018 2 KLKB1 2 SUN5 2 LIMCH1 2 LDHA 2 ADAM28 2 CTDSP1 2 PDE8B 2 C1orf112 2 KIF26A 2 TRO 2 FRMPD4 2 FAR1 2 EVI2B 2 STMN3 2 MRPS30 2 ABCC2 2 CUL3 2 ARR3 2 SYT14 2 IMPG1 2 OR9G4 2 MOG 2 LPAR3 2 SLC12A7 2 NCAPG2 2 OAS3 2 TGM2 2 RLTPR 2 CANX 2 NPR2 2 CDH16 2 NAV2 2 NHS 2 CNTN5 2 GBF1 2 MMS22L 2 TAF1L 2 IGFN1 2 ATP1A3 2 KIRREL3 2 MUC19 2 USP3 2 COMMD10 2 PRR33 2 HDAC1 2 SYDE1 2 C1R 2 ALMS1P 2 ADAR 2 AIDA 2 ZBTB6 2 FAM83G 2 PHLPP2 2 SEPT9 2 KCNA10 2 SPESP1 2 COPS7A 2 WNT8B 2 EEA1 2 RNF17 2 HSPG2 2 MUC22 2 CC2D1B 2 FAM133A 2 DCUN1D2 2 HAUS4 2 SP4 2 DSG1 2 DEPDC1B 2 TLK2 2 ATP2C1 2 EXOC8 2 KDELC2 2 FIBCD1 2 MAP3K1 2 MRC1 2 GRIN2B 2 XPC 2 UNC13D 2 MAPK8IP2 2 SLC39A13 2 FREM3 2 COL11A2 2 GRM3 2 ZNF648 2 RP11-108K14.8 2 RIT1 2 ZNF528 2 MORC2 2 PTPRZ1 2 FTH1 2 NLRC5 2 KANK1 2 HAS3 2 PMS1 2 C11orf52 2 LYPLA2 2 CD4 2 C1S 2 PML 2 MYBPC1 2 ANPEP 2 GNB5 2 EBF3 2 COL6A6 2 SETD1B 2 DAGLA 2 BOD1L1 2 DNAJC13 2 INPP5D 2 RBM27 2 TLR8 2 CSPG4 2 USHBP1 2 TP53AIP1 2 ASTL 2 CHRM2 2 SGK1 2 ABAT 2 IL20RA 2 PPP1R9B 2 KMT2E 2 DNAJC5B 2 ECM2 2 PRDX3 2 ADNP 2 HELZ2 2 TBC1D12 2 MIOX 2 ALPK1 2 BICC1 2 RP11-114H24.4 2 ATP13A1 2 THEMIS 2 NTN4 2 SLITRK3 2 ARID5A 2 BAHCC1 2 SCN1A 2 VIT 2 ZIC4 2 KDM3A 2 FAM71B 2 PRICKLE1 2 PVRL2 2 EPHB3 2 ZBTB48 2 FANCM 2 C2orf71 2 PARP10 2 UNC5A 2 IGSF22 2 CLTC 2 PPP1R3G 2 ERBB4 2 SPHK2 2 UHRF2 2 DOCK2 2 NF1 2 EIF3L 2 IGHG2 2 OR56A4 2 GABBR2 2 RP11-15H20.6 2 GAL 2 ZNF414 2 RAB11FIP5 2 CNTRL 2 PCYOX1 2 ADGRF1 2 EFCAB5 2 CALD1 2 FAM13A 2 MEGF6 2 CCDC178 2 CLCA1 2 SOBP 2 RPL4 2 PCDHB11 2 RAX2 2 VWA3B 2 USP12 2 ITIH5 2 GRIP1 2 CAPN9 2 SLC34A1 2 HCN1 2 NBPF7 2 TAF4 2 RCN3 2 ST7 2 LARP1B 2 PDZD2 2 ZBED5 2 PLEKHA6 2 BSN 2 RBBP4 2 PCDHGA12 2 ZBTB3 2 DPY19L2P2 2 TOR3A 2 PRKAG3 2 PCF11 2 ZNF587 2 AHSG 2 SIGLEC8 2 GGCX 2 ZNF536 2 NBPF12 2 PXDNL 2 NPIPB11 2 ISYNA1 2 XIAP 2 VAMP1 2 PRTG 2 DMAP1 2 POLD1 2 BZRAP1 2 TCEA2 2 RALYL 2 SPATS2 2 ARSE 2 BBX 2 SIGIRR 2 AC090825.1 2 WLS 2 OVCH1 2 CACNA2D2 2 CACNA1B 2 SNAPC4 2 PIWIL1 2 ZNF99 2 EPHA6 2 FKBP10 2 TRIM3 2 SYTL3 2 MMP17 2 TAOK3 2 NDST1 2 MYOT 2 CDCA7 2 FCHO1 2 TAF7L 2 SNRNP200 2 SPIN3 2 COL2A1 2 DYNC2H1 2 MUC2 2 COL9A1 2 PARD3 2 THSD7B 2 SLC25A47 2 NEIL1 2 WDR18 2 TNXB 2 AKAP9 2 ZMYM4 2 CDH15 2 MYH9 2 SLC27A4 2 TMPRSS15 2 STON1 2 RUNDC1 2 ZNHIT2 2 ADGRA1 2 FLG2 2 FLG 2 KIF20A 2 SEC31A 2 KSR2 2 RHPN1 2 MTHFR 2 CRIM1 2 SPG7 2 ZFP69B 2 INTS5 2 PLEKHS1 2 SOX17 2 MRVI1 2 TTC28 2 PRAMEF8 2 SLC35F1 2 TOMM70A 2 FBXO24 2 UST 2 N4BP2 2 HDAC9 2 RASSF4 2 HNRNPK 2 DAAM2 2 SEMA4C 2 RASIP1 2 OR4C6 2 MEIS2 2 RYR3 2 MKS1 2 LRRC47 2 UBQLN2 2 NOP56 2 LIN28A 2 SEPSECS 2 HDAC6 2 PKHD1L1 2 SNAP91 2 KCNQ1 2 SFMBT2 2 KIF3C 2 CCDC88C 2 DDX17 2 KIF7 2 RNF111 2 GH1 2 AKAP6 2 GAPDH 2 C3orf67 2 FAM227A 2 SERPINB13 2 CEBPZ 2 FBLN2 2 PIK3R3 2 WDR35 2 SART3 2 KARS 2 SYT1 2 ARHGAP23 2 BAZ2A 2 ZBP1 2 CTC-457E21.9 2 NLGN2 2 KMT2A 2 EDC4 2 TET3 2 COL1A2 2 ELMSAN1 2 RBL2 2 STRADB 2 ZNF281 2 TBX5 2 SOX11 2 RNF112 2 ISPD 2 TRIO 2 WDR11 2 TTBK1 2 FURIN 2 RPS7 2 PRDM16 2 OR51I2 2 PCDHA11 2 GNPAT 2 TRIM41 2 ENOSF1 2 C11orf80 2 NOL8 2 PIWIL4 2 NUMB 2 PSG6 2 NLRP1 2 NCAPH 2 EP300 2 RUSC1 2 TTC39C 2 SMPD3 2 CCP110 2 LPL 2 RECK 2 CNGA1 2 CNOT4 2 TTC37 2 PDS5A 2 ZNF236 2 ZNF773 2 ITGAX 2 ZFYVE21 2 SPINK5 2 AMFR 2 UBR4 2 MIA3 2 ITGAE 2 ZNF658B 2 DGCR8 2 ADAMTS2 2 TMEM67 2 HELZ 2 RGS3 2 COL9A2 2 SREBF1 2 MKI67 2 GPR179 2 STARD8 2 NOC2L 2 NAT8 2 HGFAC 2 MEIS1 2 CYP26A1 2 BEST1 2 ZNF350 2 APBB3 2 OR10S1 2 SLC16A2 2 HIP1R 2 NR2C1 2 RIMBP2 2 ITGA11 2 TNNT1 2 HCRTR2 2 L3MBTL2 2 ZNF211 2 LILRB2 2 SEL1L3 2 XKR6 2 POLR2B 2 LACRT 2 ZBTB16 2 DOCK5 2 MGAT3 2 NDUFS2 2 SEC24A 2 MYO1A 2 PCDHA5 2 CFAP221 2 IL9 2 POLR3H 2 TRIM31 2 VWA3A 2 RFX1 2 SMG5 2 ANHX 2 CAPRIN2 2 COL3A1 2 CYP4F11 2 FYB 2 R3HCC1L 2 ITGB1BP1 2 FRMPD2 2 ZNF48 2 UBC 2 FGFR3 2 MOCOS 2 CEP78 2 FOXF1 2 POLE 2 GCN1L1 2 SMTNL1 2 MROH7 2 ATAD2B 2 RNF214 2 PCDHGA10 2 TOE1 2 HYDIN 2 TEX14 2 SNX25 2 CXXC1 2 PPP2R1B 2 ZNF691 2 ARHGEF10L 2 ANKRD42 2 RAI1 2 CTDSPL2 2 RGPD4 2 PROM1 2 ZNF727 2 GGA3 2 DOCK6 2 ZFR2 2 CCNB1IP1 2 IFNAR2 2 ARHGAP9 2 ITPR2 2 SEC23A 2 ZNF81 2 VPS35 2 FNDC3A 2 TMEM25 2 PLAGL1 2 ADH7 2 AMER1 2 GARNL3 2 SFSWAP 2 SORCS3 2 PKD2L2 2 GRHPR 2 CHMP2B 2 OR14A2 2 SLC39A4 2 SCN10A 2 ZNF532 2 ERCC3 2 RHOQ 2 FKBP15 2 IL6 2 SLC35F3 2 ZNF469 2 SLC28A1 2 BRPF1 2 COL9A3 2 CYP51A1 2 DDR1 2 PTGER3 2 SMC1B 2 NADSYN1 2 DCST1 2 TMEM192 2 ACTB 2 BRD8 2 FNIP2 2 TXNDC11 2 TM4SF20 2 CTNNA3 2 GLI3 2 FBN2 2 TMEM134 2 FREM2 2 CCDC87 2 DNAH12 2 GNE 2 FBN1 2 ACAD10 2 UTP14C 2 ATXN7 2 GALNT3 2 DMTN 2 SOX5 2 ENPP4 2 ITPKC 2 MYO7A 2 FCN1 2 SEC14L1 2 SLC23A3 2 THSD7A 2 KIF14 2 C10orf90 2 UBE3B 2 TTC34 2 XXbac-BPG116M5.17 2 MTUS2 2 C12orf29 2 RBM34 2 KIAA0232 2 NPTX1 2 NEDD4 2 GIGYF2 2 FBP2 2 GAS2L2 2 RBM12B 2 CHST1 2 MYO18A 2 RNF32 2 ACSF2 2 MTX1 2 UGGT1 2 MLYCD 2 AQP3 2 RBM10 2 ALDH2 2 USP15 2 THPO 2 LRRC37B 2 PDIA2 2 CACNA1C 2 CABIN1 2 RSC1A1 2 SORCS1 2 MLK4 2 AR 2 FBRS 2 TMEM60 2 GMCL1 2 OTOP2 2 GPR139 2 AKIRIN2 2 WNK1 2 KCNH2 2 SLC13A2 2 NAPSA 2 ACTN2 2 PCDH12 2 GTF2H3 2 SETBP1 2 PARD6B 2 DDHD1 2 JMY 2 CST9LP1 2 ADCY5 2 MSH2 2 FBXL16 2 ZC3H4 2 EXOSC8 2 HFM1 2 VWDE 2 USP17L2 2 MAN2A2 2 ENPEP 2 SPTBN2 2 MAMDC4 2 IQGAP2 2 FAM208B 2 JMJD1C 2 PITPNM3 2 FANCI 2 MCCD1 2 NAGPA 2 HS3ST3A1 2 ZC3H7A 2 MLC1 2 ZMYM2 2 POLR1A 2 IRS2 2 DHX37 2 KLF15 2 INTS6 2 PCDHA3 2 KRTAP9-4 2 ZNF687 2 LDLR 2 DNAAF3 2 ADAM19 2 ZMIZ1 2 PHIP 2 EBF1 2 ABCC10 2 ADHFE1 2 DNMT3A 2 DNAH6 2 ZNF721 2 NOD2 2 CEACAM21 2 GRM1 2 CALB2 2 PDPN 2 DCAF7 2 HIVEP2 2 C9orf3 2 UHRF1BP1 2 SUPT16H 2 DPYD 2 ABCA1 2 SPTLC2 2 GPATCH8 2 CACNB2 2 ANKRD11 2 AKAP12 2 MYO1D 2 SH3TC1 2 ACAN 2 SSFA2 2 CDC14C 2 CERKL 2 RNF11 2 RRP7A 2 PCDH11Y 2 HIVEP3 2 C5 2 USP38 2 PRKCG 2 HYKK 2 CASC5 2 RIN1 2 ADGRL3 2 SOGA1 2 JUP 2 FBXL18 2 PIGN 2 CHD4 2 DNAH10 2 CCNO 2 CENPT 2 PLXNB2 2 AQR 2 PRSS27 2 OR52N2 2 TCF20 2 UGT3A2 2 WDR78 2 CSF1R 2 MCM10 2 KEAP1 2 MED13 2 MLXIP 2 PCK1 2 NMD3 2 ACADM 2 NOTCH2 2 PFKL 2 OLIG1 2 DOK7 2 ZSCAN10 2 POLR2G 2 NPC1L1 2 HIF1A 2 HPN 2 ITLN1 2 BBS5 2 AP4B1 2 ZNF205 2 TENM1 2 GPATCH1 2 HERC2 2 ABHD3 2 ZNF44 2 KCNH7 2 PTPRT 2 BRMS1 2 ZNF716 2 SNX2 2 MAPK6 2 FAM122A 2 ZNF611 1 NUMA1 1 PYGM 1 SEMA3A 1 TRIM38 1 NAALAD2 1 ZNF75D 1 RFC5 1 INHBE 1 NFATC4 1 FSCB 1 RNF144B 1 ZBTB10 1 GKAP1 1 CRCT1 1 MYCBPAP 1 C9orf172 1 KIR3DL3 1 FAM212A 1 TMEM79 1 DICER1 1 YIPF3 1 ANKS1B 1 STARD7 1 FAM168A 1 DGKB 1 LPGAT1 1 RUFY3 1 RP3-416J7.5 1 SCARA3 1 C10orf54 1 MDGA2 1 GPR52 1 ABCC9 1 GLTSCR1 1 ABHD17A 1 SMAD6 1 STK36 1 PRSS23 1 CDK5 1 NRDE2 1 ARMC9 1 MIR498 1 ERRFI1 1 BEND3 1 ITGAD 1 SDAD1 1 SLC14A2 1 CD276 1 TIMD4 1 NFRKB 1 RGS20 1 CLDN10 1 KIAA1524 1 ZXDB 1 SPEN 1 REG1B 1 CAPS2 1 TBC1D3P1-DHX40P1 1 MAMDC2 1 TUBB7P 1 UQCR10 1 CEMP1 1 PDXK 1 AVEN 1 KRT24 1 MYO9B 1 CHST10 1 MDM1 1 ADAM18 1 LY6E 1 ASPSCR1 1 PRSS1 1 BORA 1 ZNF25 1 CORO2B 1 RASA3 1 SLC12A5 1 TBL2 1 MGAT5 1 RSU1 1 C2orf48 1 TMEM8A 1 ELMOD2 1 ABLIM1 1 RECQL 1 IGSF9 1 RP11-337C18.8 1 NKRF 1 ALS2CR11 1 OR5B17 1 OPRD1 1 RPUSD2 1 PSMD14 1 KCTD20 1 RXFP3 1 TMPRSS3 1 C9orf9 1 SSC4D 1 DPH5 1 ESR1 1 IGFLR1 1 SDE2 1 CXCL12 1 GCC1 1 GRPEL2 1 EP400NL 1 OSBPL2 1 OR2Z1 1 IER5 1 FAM182A 1 DDX43 1 KRT13 1 PPARGC1B 1 TADA2A 1 CAMKK1 1 ATP9B 1 LSM14B 1 ITIH2 1 DNAJC14 1 SRRM4 1 LRRC63 1 LY75 1 SLCO4A1 1 PYGB 1 IGFBP3 1 MSH3 1 GPBP1L1 1 ITIH4 1 CELF3 1 TMEM37 1 MORN4 1 ACTL9 1 PLXNC1 1 NLGN3 1 OCA2 1 ZNF676 1 SENP6 1 KBTBD11 1 PLEKHA5 1 CDCA2 1 YBX3 1 EIF2S3L 1 ZNF534 1 OR5J2 1 RGS7 1 ALG13 1 ACIN1 1 KANSL1 1 ZNF432 1 ZNF496 1 ASS1 1 TPT1 1 NR3C2 1 RNASE1 1 OR2L2 1 B3GALNT2 1 PARP9 1 MEN1 1 CFAP58 1 MYBPC3 1 USP6NL 1 TRIM60 1 TMC4 1 SPDYC 1 GFI1 1 LHX5 1 FLVCR2 1 OR9A4 1 RBM4B 1 MERTK 1 RIC8A 1 CPPED1 1 CDC37 1 CHST3 1 MRPL48 1 FGFR4 1 STXBP1 1 POU3F3 1 SRRT 1 NUP210L 1 MBTPS2 1 MTERF4 1 AMH 1 AC092675.3 1 FLT3 1 CNOT11 1 MAPK8IP3 1 TMPRSS13 1 C4orf17 1 LYPLA2P2 1 FOXM1 1 SLC4A9 1 RGS12 1 ADIRF 1 MEIS3 1 ERLIN2 1 KIT 1 CBX2 1 SOCS5 1 SPRED1 1 MAPK9 1 IGHA1 1 C11orf30 1 SETDB1 1 ATP10A 1 NXPH4 1 NUP210 1 RBM47 1 PDLIM7 1 ABHD17C 1 PDCL3 1 HTR5A 1 DEFB134 1 ACSS1 1 ATAD3C 1 TGFBR3 1 FAM53B 1 ZNF92 1 TCHH 1 PLIN1 1 SEC1P 1 LZTR1 1 KRBA2 1 DNM2 1 CCDC170 1 KLHL33 1 PARD3B 1 MFGE8 1 ACAA1 1 LHX3 1 AKNAD1 1 NHEJ1 1 LRP5 1 NUP93 1 RNF138 1 IGKV1-27 1 UBXN4 1 NCKAP1 1 SDCCAG8 1 LAMB1 1 TSC1 1 IRF7 1 RHOXF2 1 TMEM239 1 STK38 1 CCDC129 1 YJEFN3 1 ALKBH6 1 KDR 1 ADRBK1 1 VSIG10L 1 BTF3L4 1 GLT8D2 1 ULK2 1 PPP4R1L 1 PMPCB 1 CMPK2 1 RTN4R 1 ATP6V0A1 1 TBX2 1 OTUD6A 1 RPSA 1 PPP1R16A 1 RANBP9 1 NELL1 1 C4orf36 1 FAM228A 1 THBS2 1 TUBB4B 1 PCSK1 1 DPH1 1 TCEB1 1 MDM4 1 NPAS4 1 CCDC186 1 BRD3 1 DUSP21 1 MATN1 1 UBE2Q1 1 SIPA1L1 1 SLC6A15 1 TOMM6 1 AKT1 1 PARP11 1 B3GNT6 1 YARS 1 HNF4A-AS1 1 FRMD4B 1 OR4E2 1 PLAC8 1 IVNS1ABP 1 IL21 1 FAM198B 1 CRB1 1 GLRA2 1 OR2A14 1 FMN1 1 CRTAC1 1 DNAJC11 1 FSCN1 1 PDP2 1 FAM117A 1 LITAF 1 RPS6KA2 1 HMGN1 1 LRP6 1 MPP7 1 PDZD7 1 UQCRB 1 MRPL16 1 ADM2 1 ANXA2R 1 TNNT3 1 CEP63 1 HK2 1 GRAP2 1 APAF1 1 NEFM 1 EXOSC2 1 FOXD4L4 1 OR52R1 1 EHMT1 1 HJURP 1 GPRASP2 1 NUDT4 1 SCCPDH 1 SNX20 1 HUS1B 1 KCND1 1 CHRNA2 1 MAP2 1 GOLT1B 1 ANG 1 ARHGEF33 1 RP11-545J16.1 1 GRIN2D 1 LRRC37A3 1 KNG1 1 VSX1 1 PCCA 1 HEXB 1 NR6A1 1 CTD-3074O7.11 1 CTBP1 1 ARHGAP17 1 CEACAM7 1 SIGLEC7 1 FKBP11 1 RGL2 1 SETD5 1 SPANXN5 1 SLC4A2 1 RAB11FIP4 1 MAP1S 1 ULK1 1 DNMT3L 1 SPPL2B 1 DOCK1 1 PDHA1 1 PWWP2B 1 CRYM 1 SOAT1 1 ZBTB21 1 ANKS3 1 NAALADL1 1 DKK4 1 OR10X1 1 ZNF679 1 PPFIA2 1 NBPF14 1 KIAA1324L 1 ZNF142 1 TMEM232 1 PRR30 1 SNORD114-24 1 MKNK1 1 TBC1D19 1 ALKBH8 1 ARRB1 1 SLC44A1 1 GALNT2 1 WDR86 1 PRRC2B 1 MPEG1 1 KCNU1 1 UBR1 1 RCE1 1 SLC32A1 1 MFHAS1 1 CKMT1A 1 C1QTNF2 1 CUL2 1 HRC 1 RGS11 1 DPH7 1 B4GALNT4 1 OR10G9 1 AMBN 1 PPL 1 SPANXN4 1 SLC16A1 1 KCNA6 1 FUT5 1 UNC79 1 USP39 1 AGBL5 1 TNPO3 1 TRHDE 1 STARD6 1 CPEB2 1 NFATC2 1 PCDHB12 1 ZHX3 1 LCN9 1 CAGE1 1 SLC22A17 1 FADS2 1 SMCHD1 1 SMPD4 1 TDRD9 1 DNASE1 1 LRBA 1 ODAM 1 PTGES3L-AARSD1 1 EFNB3 1 CRYGC 1 ACTR3B 1 HINT3 1 WFDC9 1 OR2F1 1 FGFR2 1 OR52N1 1 CDH7 1 GTF3C5 1 ZSWIM4 1 C8orf22 1 KRTAP4-4 1 GUCY2D 1 NUCKS1 1 SLC6A18 1 FAM103A1 1 PCDHB7 1 FAM193B 1 CDKN2A 1 ZC3H11A 1 CEP135 1 CFI 1 HIST1H2BI 1 SNX9 1 CALR3 1 SCN5A 1 STAMBPL1 1 BCL2 1 SLC38A1 1 NPC2 1 TIMM44 1 HIST2H2AC 1 NUP214 1 POTEE 1 HEPHL1 1 LIPT2 1 PVALB 1 TCF7L1 1 MSL1 1 ELP2 1 TMEM131 1 ZNF692 1 GNAO1 1 PFN4 1 TNFRSF10B 1 ZNF235 1 BBS7 1 KRT75 1 THEM4 1 GLIS1 1 MGAT4C 1 PTK2 1 AC104809.3 1 ABCC3 1 POU4F3 1 TRAV6 1 DMRTA1 1 SLC25A44 1 MAN2A1 1 CYLC1 1 PRSS58 1 RHCG 1 DDX53 1 TTLL12 1 NXPE1 1 TGFB2 1 POC1B-GALNT4 1 RAB35 1 SLC35B4 1 ROBO2 1 TBC1D9B 1 DAB2 1 DCTN4 1 RNASE10 1 COL4A5 1 GLCCI1 1 PHF10 1 HSPA6 1 HSF1 1 HAO2 1 KRT6A 1 DCTN6 1 NDRG3 1 PDLIM2 1 SLC25A17 1 DHCR7 1 RHAG 1 FKBP8 1 RDH13 1 POLR2C 1 MAGEB5 1 SLC6A3 1 SLFN14 1 ZNF74 1 CDK5RAP2 1 PUF60 1 TM4SF1 1 SLC9A1 1 AJAP1 1 DAOA 1 DISP2 1 CYP2A13 1 MMP26 1 EFR3B 1 RP11-766F14.2 1 SSC5D 1 PRKAR1A 1 EBAG9 1 PRMT7 1 RAB3GAP1 1 OR8K1 1 SPRY2 1 TSKS 1 GBP3 1 ZNF667 1 RP11-393I23.4 1 FAM26D 1 ADAM20P1 1 MAPK8 1 MRE11A 1 RTEL1 1 ASCC3 1 PLCB2 1 TMOD3 1 RNASEK 1 WAPAL 1 PPP2R3A 1 PDGFRL 1 ZNF780B 1 IL18BP 1 TEDDM1 1 ULK4 1 SNORD115-14 1 SLC26A2 1 CPNE5 1 OPRL1 1 EYA1 1 MEF2A 1 C16orf89 1 RABGGTA 1 DGUOK 1 SP5 1 NYAP1 1 ASH1L 1 LPPR4 1 MRFAP1L1 1 KIAA1522 1 RPAP1 1 TM2D2 1 TDP2 1 KREMEN1 1 GATA4 1 NACAD 1 CFL2 1 GPRASP1 1 RASA2 1 ABCG5 1 CETP 1 GRID2IP 1 KIF16B 1 TMPRSS11D 1 MAPK4 1 C10orf71 1 LPXN 1 GALE 1 NEO1 1 TRIM24 1 TOP1MT 1 NAIP 1 PRKAA1 1 FRMD3 1 CPED1 1 ANKRD10 1 MARK4 1 TMBIM4 1 NUTM2B 1 IL34 1 MED25 1 BTN3A2 1 BSPRY 1 SDS 1 OIT3 1 SPATA31C2 1 CADPS 1 PTPN20CP 1 TKTL2 1 SCAP 1 KPNA4 1 RAD21 1 NDFIP2 1 MAEL 1 RPLP1 1 MS4A6A 1 CHAT 1 ZSCAN21 1 FBXW5 1 PLCE1 1 ABCG2 1 G6PC 1 ASAP1 1 DNAJB5 1 REG3G 1 LRRC10 1 RPL18A 1 RP11-116D17.1 1 GCKR 1 ITGA7 1 KIAA1614 1 C18orf63 1 MTHFSD 1 SPATA20 1 FNDC1 1 LAD1 1 BCLAF1 1 ZFAND3 1 SLC1A5 1 PAX3 1 EPHX2 1 C15orf52 1 IL20RB 1 MTO1 1 TRIM6-TRIM34 1 PDE5A 1 GABRA2 1 PDIA5 1 LRPPRC 1 ZNF512 1 TRANK1 1 AC073621.2 1 GRASP 1 DSPP 1 SUPT6H 1 ARHGAP19 1 WHSC1L1 1 SPATA31D5P 1 TNK2 1 EPS8L1 1 PLEK 1 PIK3C2G 1 C17orf100 1 SLC26A1 1 AIF1 1 OR2J2 1 LILRA4 1 ZNF513 1 KRTAP19-7 1 FAM46C 1 HTR1E 1 ATL2 1 RBM33 1 HDX 1 OCSTAMP 1 MMP13 1 MYO3B 1 FASTKD5 1 PTPN22 1 TMEM132A 1 C7orf50 1 TCFL5 1 SERPINA12 1 AHDC1 1 PLET1 1 RSAD1 1 FBLN7 1 WRB 1 ATP5L 1 DHDH 1 ATP8A2 1 SERINC1 1 AZIN1 1 OR8D4 1 GPR3 1 BATF2 1 DSG2 1 PARP15 1 CLUAP1 1 RBM48 1 CDKN2D 1 KLHL25 1 KCTD8 1 BIRC8 1 USP2-AS1 1 UBAP1L 1 OR9Q1 1 PNLDC1 1 SAG 1 DMRTB1 1 EXTL1 1 OR3A2 1 ZNF439 1 LIFR 1 SLC19A3 1 UGT2B4 1 RHEB 1 GPC4 1 MMP14 1 CRHR2 1 CDC42BPG 1 SGMS2 1 NLRP13 1 MELK 1 HOOK3 1 SMURF1 1 RPL22 1 KRCC1 1 CRAMP1L 1 DRD4 1 CCDC141 1 TRPC6 1 KCNG2 1 LEO1 1 C16orf13 1 TCOF1 1 DCHS2 1 KCNH6 1 MYO15B 1 CCDC40 1 PNPLA6 1 MSANTD3 1 NUTM1 1 NOTCH1 1 ZNF226 1 OR8B8 1 STAC2 1 STOML2 1 GSDMC 1 MFSD6 1 VEZF1 1 CCAR2 1 C1orf64 1 WDR36 1 OTUD7B 1 FGL1 1 ERMN 1 FBXO22 1 SPP1 1 GJA9 1 ARIH1 1 ZNF597 1 KCTD17 1 TMEM168 1 CXorf40B 1 C1QL4 1 KPNA3 1 DHX36 1 GALNTL5 1 C16orf91 1 ZNF792 1 SYTL5 1 NKAPL 1 CPXM2 1 FSBP 1 NAP1L1 1 EFHB 1 RP1 1 ASIC4 1 ISG20 1 LRRC66 1 OR1S1 1 MTDH 1 MTFR1L 1 C19orf66 1 ZNF780A 1 ZNF554 1 EMG1 1 TANC1 1 UBE2A 1 TPO 1 CPN2 1 MYCT1 1 ATP5A1 1 IGHV4-39 1 BCAN 1 FRAS1 1 AP1AR 1 TACSTD2 1 GNAT3 1 OTOA 1 SDCBP2 1 CDK10 1 ADGRE4P 1 TTC21B 1 MDN1 1 EPHA4 1 PRSS8 1 ASIC2 1 F8A1 1 FOXR2 1 PKDREJ 1 RP11-407N17.3 1 MTMR4 1 CNTN3 1 TGM7 1 WDR70 1 ADIPOR2 1 CFAP45 1 C3orf20 1 SPECC1L 1 JMJD4 1 ZNF777 1 LRRC75A 1 NWD2 1 C15orf59 1 RP11-61L23.2 1 MSANTD1 1 KIAA1467 1 RAB3IL1 1 LAT 1 RDX 1 HDAC7 1 FIGN 1 CASP5 1 CD163L1 1 USP53 1 PDE1C 1 F2RL1 1 KCNT2 1 FAM186B 1 RILPL1 1 ADAM33 1 METTL25 1 CDHR3 1 NDUFS8 1 CTC-242N15.1 1 POLG 1 OCEL1 1 PCDH17 1 DEF6 1 AP3M1 1 SAMD13 1 C8B 1 INPP5F 1 TRIM37 1 IMMT 1 TRMT2B 1 RP11-26J3.4 1 SNX18 1 ZNF850 1 ITGA4 1 B3GNT8 1 UBP1 1 SLC16A12 1 FAM149B1 1 PLOD1 1 PNPLA1 1 DHX8 1 PLA2G6 1 YWHAH 1 AGXT2 1 HKR1 1 MEX3B 1 CPOX 1 YWHAZ 1 ZNF541 1 TMEM210 1 PDE4B 1 EEF2K 1 C1orf159 1 ZC3H3 1 ZIC1 1 GBA2 1 RAB38 1 ZNF79 1 SNCB 1 MME 1 HEXDC 1 TECRL 1 RPL38 1 TIGD4 1 RBM38 1 ACO2 1 CDH17 1 NR3C1 1 OR52A1 1 SASS6 1 AKAP11 1 LRRC1 1 TFF3 1 MIR30C2 1 MRPL28 1 ZBTB34 1 LYPD3 1 PEAR1 1 LIPA 1 PCDHA8 1 KCNC3 1 DUSP12 1 EIF5A 1 KRT2 1 CCL11 1 UPF1 1 TTLL7 1 DRD5 1 NPY 1 MINA 1 RBKS 1 LRRC41 1 PTH2 1 NBPF26 1 TSR1 1 ETV6 1 MS4A4E 1 SLC9B1 1 MAGEB2 1 THAP3 1 SLC25A33 1 RAD23A 1 CYP2A6 1 ESF1 1 DFNB59 1 TMPRSS6 1 ZDHHC5 1 ADGRF4 1 CD209 1 ASPHD2 1 HNRNPH1 1 ACPP 1 PCDHGA7 1 SYNRG 1 NT5M 1 DMRTC1 1 DPY19L1 1 FBXO40 1 ZNF256 1 ZNF274 1 GIPC1 1 SAYSD1 1 PDE7A 1 NNMT 1 CHRM3 1 TSIX 1 PHLDB3 1 PSMD2 1 HP 1 SH3PXD2A 1 OR5P3 1 CHTF18 1 ANKRD33 1 KLHL29 1 MYH7 1 CPD 1 SERINC5 1 GPR6 1 PPAN-P2RY11 1 USP43 1 GON4L 1 ADAMTS5 1 GPM6A 1 IGDCC4 1 UMAD1 1 SGCZ 1 IRF8 1 ZFPM2 1 KIAA0319 1 GSN 1 SNX11 1 SYPL1 1 PLEKHM3 1 PDCD6IP 1 NSDHL 1 BACE1 1 CLCNKB 1 PRSS54 1 KRR1 1 ZNFX1 1 C9orf43 1 CHD1 1 TRIM36 1 KRTAP1-4 1 KRTAP10-9 1 KCNK3 1 ETNK1 1 PHF23 1 CARD11 1 APCDD1L 1 ANKRD17 1 TOMM7 1 NDUFAF1 1 MOB2 1 TAF1B 1 TDRD15 1 NEUROG1 1 MPO 1 ANKIB1 1 OR10A3 1 PATE3 1 RCOR2 1 AMIGO1 1 MST1L 1 MYZAP 1 SERPINE2 1 MC2R 1 SGCB 1 MEI1 1 SLC13A4 1 SLC37A3 1 KLHL7 1 MAGEB18 1 TRPV6 1 ANKRD39 1 FAM135A 1 EPG5 1 SMIM8 1 PPA1 1 SLFNL1 1 CWC25 1 OR52J3 1 ACSL3 1 DUSP27 1 PTGR2 1 RAD21L1 1 ST20-MTHFS 1 PLEKHG4B 1 AGFG2 1 SOX14 1 CEP126 1 VN1R4 1 IRGQ 1 POGK 1 IFFO2 1 ZFYVE26 1 POU6F2 1 YEATS2 1 HSD17B13 1 TFIP11 1 MB21D2 1 CLDN2 1 LRRC71 1 NOX4 1 ATG9B 1 LIN52 1 ORAI3 1 KCMF1 1 SCNN1B 1 GRIA1 1 PAK1 1 CDK16 1 CHI3L2 1 SUMO2 1 CD81-AS1 1 GIMAP6 1 CCDC173 1 GBA3 1 PYCR2 1 ZNF865 1 SQSTM1 1 KRT6B 1 PHC3 1 ZSWIM7 1 ZBTB39 1 PANX3 1 ANXA4 1 ZNF555 1 PLCH2 1 TRNAU1AP 1 TP53BP2 1 SEPT2 1 FAM120AOS 1 MPPED2 1 TTC7A 1 SALL4 1 LRFN4 1 ATP6V1B1 1 ANGPTL1 1 MTMR14 1 MATN2 1 TCF23 1 GATA3 1 SH2D6 1 NANOS3 1 NEK4 1 SEL1L2 1 KCNAB3 1 NRSN1 1 COX7B2 1 TATDN2 1 CAMTA1 1 UMPS 1 COPZ2 1 ABCA2 1 DMKN 1 ARCN1 1 PPM1A 1 RSRC2 1 GALNT1 1 OLR1 1 PDE6A 1 SLC9C2 1 DLL1 1 TMC5 1 PID1 1 PSMB10 1 TRPM7 1 CEBPA 1 CCDC176 1 PDCD2L 1 PRMT2 1 IL36RN 1 SLC35G5 1 TLK1 1 PTGER4 1 CNDP2 1 TSEN2 1 RNF121 1 MTX3 1 ASPM 1 ARHGAP30 1 CIRH1A 1 RP11-171N4.2 1 WDR34 1 DDX18 1 CYS1 1 ANKRD1 1 EZH2 1 ZRSR1 1 IGFBP7 1 COL7A1 1 RASGRP2 1 GIMAP1 1 PAK4 1 LGI3 1 BDP1 1 TRHR 1 LDLRAP1 1 SLC16A11 1 SV2A 1 DVL1 1 FUK 1 AK3 1 AC002365.5 1 PTCH1 1 SVIL 1 PARG 1 ELL2 1 UNC93B1 1 C12orf56 1 SPG20 1 CSTL1 1 SCN2A 1 OTUB2 1 EIF2AK4 1 ECHS1 1 TNN 1 TMEM258 1 GPR17 1 REPS1 1 DUS2 1 RRM2 1 MAPK1IP1L 1 SRSF4 1 FAM184B 1 ZWINT 1 KXD1 1 OVGP1 1 PDE6B 1 PRR19 1 GPR1 1 C15orf41 1 SLCO4C1 1 COMP 1 ATP1B1 1 HOXD10 1 GPS2 1 PEX1 1 TIGD5 1 SLC4A10 1 ATP1A1 1 IDO1 1 HELQ 1 SPON1 1 PRKG1 1 CCDC96 1 ILVBL 1 RNF133 1 SLC16A7 1 TRAPPC2L 1 ANKRD6 1 QRICH1 1 ZNF200 1 SH2D4B 1 PTGR1 1 FSD1 1 FEN1 1 BAG2 1 ZFP28 1 HCG17 1 DCXR 1 KRTAP5-8 1 VLDLR 1 SLX4IP 1 SMARCD2 1 CCDC114 1 CD151 1 PCDHB10 1 WDR47 1 SHISA3 1 LRWD1 1 SKIV2L2 1 DISC1 1 NT5E 1 C15orf57 1 SULT4A1 1 ZNF331 1 FFAR1 1 VASP 1 TIGIT 1 POP1 1 TMEM156 1 TCEB3B 1 RPS6KB1 1 CFAP46 1 LAMB3 1 CDKL5 1 TMEM245 1 DOCK4 1 PSMA7 1 PDGFRA 1 PEX5L 1 SESN1 1 PRR14 1 PCDH8 1 PCDHAC2 1 FBXO47 1 TCF25 1 VIPAS39 1 CEP76 1 ZNF525 1 TLE3 1 TMEM178B 1 MAN2C1 1 GPR84 1 LRRC46 1 A2ML1 1 TCEAL4 1 MYO5B 1 EFCAB13 1 TJP2 1 DPP10 1 NCOR1 1 MAP4 1 DIDO1 1 CCT6A 1 CERS1 1 GUSBP1 1 TTC26 1 CYB5R4 1 SFXN4 1 AXIN2 1 TP53RK 1 MSX2 1 SPTBN1 1 CTNND2 1 LRRC53 1 CEMIP 1 PPP1R12B 1 MTMR12 1 SPEF1 1 EHBP1L1 1 DXO 1 MED16 1 MAGEE2 1 TPST1 1 FAM126A 1 CNOT6L 1 INPP4A 1 SLC44A3 1 NT5C2 1 FAM46D 1 AADAT 1 SLC1A2 1 RSPH6A 1 ZFPM1 1 MROH5 1 MYH10 1 TEKT1 1 ERCC6L 1 YOD1 1 SKAP2 1 CUL7 1 PIGS 1 FOXB2 1 EEFSEC 1 STX4 1 TSFM 1 TDRD12 1 CPNE3 1 SH2D3C 1 MAP3K4 1 TSPAN1 1 CMTM2 1 PTBP3 1 ADGRG1 1 SERPINA6 1 DDX24 1 CREB5 1 COG5 1 ADAMTS8 1 PTPN12 1 ARFGAP3 1 RASAL1 1 PHF5A 1 GPX6 1 TMEM11 1 PTCD2 1 GRM6 1 CACNG8 1 BLOC1S3 1 SEPT3 1 WDR26 1 WBSCR27 1 ZNF789 1 AGTR2 1 AIM1 1 KRTAP4-12 1 MRPS22 1 CSNK1E 1 PITRM1 1 B3GNT9 1 C19orf47 1 SHANK2 1 KRT3 1 STIL 1 DCAF8L1 1 EIF2AK3 1 FMO6P 1 IGHM 1 CP 1 UBXN8 1 TUBA4A 1 NEURL1B 1 MBD3L2 1 SAMD9 1 ZNF417 1 ATP13A4 1 TACR1 1 WTAP 1 PTK7 1 BRE 1 JAK3 1 LFNG 1 PRKAG2 1 APOA1BP 1 ARHGEF37 1 HSPA5 1 FLT1 1 GXYLT2 1 CCR7 1 EDNRB 1 MEX3A 1 EDN3 1 LAMA4 1 DGKA 1 PIGR 1 ADGRD1 1 TGIF1 1 TRIM49D1 1 GPIHBP1 1 TYR 1 GPR108 1 IFT81 1 SCAF11 1 FAM90A10P 1 BMI1 1 C11orf63 1 FKBP9 1 KLHL22 1 BHMT2 1 HNRNPUL1 1 ZNF518A 1 WWTR1 1 NUDC 1 SAMD4B 1 HPGD 1 C1QB 1 FOXO6 1 SLC22A7 1 ADAMTS14 1 SAV1 1 DNMT1 1 HBG2 1 ZNF814 1 SV2C 1 THNSL2 1 FAM63A 1 CIRBP 1 EPHA3 1 HARS2 1 PCDHA7 1 SAMD8 1 KLC3 1 KYNU 1 TBC1D30 1 GABRQ 1 MCTP2 1 ZSCAN2 1 SPTY2D1 1 KIAA0825 1 ZFY 1 SYNJ2 1 ITGB6 1 SFPQ 1 CEACAM5 1 MMP11 1 PKD1P6 1 RNF181 1 CACNA1G 1 GOLIM4 1 ARPC1B 1 P4HB 1 SSH1 1 ZHX2 1 TACC3 1 BUB1 1 ARHGEF16 1 ZBTB7C 1 ZDHHC11 1 PGM1 1 KRTAP19-5 1 USH1G 1 OXER1 1 SCGN 1 FBXL7 1 BTBD3 1 GRSF1 1 ARMC7 1 SPATA7 1 SEC23B 1 NME4 1 LCE2C 1 SUV420H1 1 CEP192 1 RPL3 1 CYP2B6 1 SNX4 1 NRN1L 1 DYNC1I2 1 MYL7 1 ADAD1 1 ADCK2 1 TMEM191B 1 ELMO1 1 PWP1 1 PCNXL3 1 RGMA 1 COPZ1 1 CFHR3 1 GNAS 1 KIAA1324 1 KCTD3 1 HLX 1 ESRP1 1 KRT20 1 KRBA1 1 CNPY3 1 C16orf87 1 DUOXA2 1 ZNF252P-AS1 1 FAHD2A 1 KIF13A 1 PPP2R2A 1 CHSY3 1 RPL5 1 ACAT1 1 SEMA3B 1 UBTD1 1 NEFH 1 KAZALD1 1 PIGG 1 RP11-206L10.9 1 MLLT3 1 AGAP6 1 MIDN 1 INMT 1 DUS3L 1 TMEM132E 1 DQX1 1 MFSD9 1 TLN1 1 SORT1 1 PPCS 1 OSBPL3 1 GSTM2 1 CGN 1 NTM 1 DHX34 1 ZNF106 1 MBTPS1 1 ENO3 1 ENKD1 1 RCBTB2 1 P4HA2 1 CACNB3 1 SPTBN5 1 PDIA4 1 CDCA3 1 SIDT2 1 PRRC2C 1 NCAPD2 1 CCDC28A 1 HSD17B1 1 OR5D18 1 FANCL 1 FN3K 1 HSD3B1 1 ERBB2 1 CA10 1 WDSUB1 1 ABCC5 1 ANKHD1-EIF4EBP3 1 PSMD11 1 ATXN2 1 RGS14 1 RTKN 1 FGF16 1 ZPBP2 1 PRDM1 1 HMGCR 1 RRP9 1 RBM19 1 HMG20A 1 MYL6B 1 ACADS 1 AFAP1 1 RBPJ 1 CACNA2D4 1 MAP1B 1 ZNF382 1 LPCAT2 1 SNRNP40 1 EPB41L4A 1 MTRF1 1 ZNF492 1 CFAP20 1 CAPN5 1 MXRA5 1 PCDHB1 1 DNAJC10 1 CRY1 1 DMTF1 1 TSPYL1 1 ZFPL1 1 SLC25A21 1 MIR873 1 SFTA2 1 DYM 1 ABCB5 1 C11orf57 1 LRRC52 1 HSD17B4 1 FER1L5 1 KRTAP10-5 1 CD1C 1 DSEL 1 TMPRSS9 1 FIS1 1 ZNF680 1 CLDN16 1 YIPF5 1 FOXN4 1 SIN3A 1 CTNNB1 1 FAM181A 1 GOT1 1 ADAM32 1 RNPS1 1 ATP11B 1 OSGEPL1 1 SLC13A1 1 CCDC73 1 TRAV10 1 GBE1 1 CYP7A1 1 PIP5K1C 1 UACA 1 CARD9 1 ZFP91 1 ZP3 1 SLC6A5 1 LRRC7 1 ESPN 1 FAM170A 1 SEMA3D 1 ATP6V1C1 1 HFE2 1 PLCG2 1 BEND5 1 UBA7 1 PLSCR1 1 ZNF324 1 STAU2 1 APMAP 1 KIAA1328 1 BRWD1 1 BMP6 1 RARB 1 POC1B 1 TARM1 1 INTS2 1 ANKRD53 1 AGTRAP 1 ANXA7 1 TSHR 1 ANXA3 1 SLC2A1 1 TRPM5 1 TRIM51GP 1 LUZP4 1 PCED1A 1 PRKACA 1 AMPH 1 NLRP9 1 MED11 1 PDLIM5 1 TMCO5A 1 DPY30 1 PTBP1 1 C5orf24 1 PRPF19 1 LGALSL 1 DYNC1LI2 1 ZNF343 1 FAM104B 1 AC069213.1 1 NUDCD1 1 MCMDC2 1 RGP1 1 DUS4L 1 GTPBP8 1 GCG 1 PHACTR1 1 SNORD116-3 1 ECI2 1 VPRBP 1 CNNM2 1 CLUL1 1 SYCE1L 1 ZYG11B 1 FAM9A 1 SMTN 1 ARL6IP5 1 DOCK9 1 WDR61 1 OR9G1 1 TCL1A 1 OR5T3 1 SKIV2L 1 OR4S2 1 DNAJB13 1 COL5A3 1 ALG10 1 PGRMC1 1 CDC16 1 TMEM145 1 ARID1A 1 PLCD4 1 LCE3A 1 HS3ST3B1 1 NEU1 1 LANCL3 1 LPAR6 1 ZFAND4 1 CYP2E1 1 BIVM-ERCC5 1 FRRS1L 1 RP11-96P7.1 1 CTC-512J12.6 1 PRF1 1 CAPN8 1 SMPDL3A 1 TMEM68 1 TMC2 1 N4BP1 1 UBE2D2 1 GTF3C3 1 ERH 1 DDR2 1 FMO5 1 KANSL2 1 MAP3K14 1 KAT2A 1 PRIMA1 1 TMEM59 1 JAM2 1 HPSE2 1 ADAM23 1 PTPN5 1 ARHGEF2 1 G2E3 1 RPL14 1 DYRK3 1 IFIT3 1 ZNF213 1 EIF2AK1 1 C22orf34 1 ARAP2 1 RIBC1 1 ZNF546 1 LONRF2 1 USP6 1 CSN2 1 SDF4 1 C5orf56 1 UBE2L3 1 PDPK1 1 BTBD18 1 LONRF3 1 LRRC8D 1 KIAA1841 1 TJP3 1 KCND3 1 GNGT1 1 ATP5B 1 HSF4 1 LRCOL1 1 SLC2A4RG 1 DDX50 1 GPATCH2 1 SH3D21 1 HOXA1 1 GRIK2 1 STIM1 1 KIAA0930 1 SUSD4 1 KHK 1 SP100 1 PAPOLA 1 FHL1 1 SUSD6 1 CD72 1 S100A10 1 ORMDL2 1 GABRR2 1 KRT7 1 PRG4 1 KLHL36 1 KATNAL1 1 TNS4 1 GMEB2 1 CCM2 1 HHLA1 1 TTI1 1 FAM227B 1 RGS6 1 DDX59 1 SSUH2 1 ST5 1 MFI2 1 PRRT1 1 SNRNP27 1 COPS2 1 DEFB118 1 QPRT 1 CRYBA1 1 TNRC6B 1 PCDHGA9 1 SCN1B 1 C12orf4 1 CHD1L 1 MATN4 1 ARHGAP24 1 AOC3 1 LYZL2 1 RPP21 1 NCAPG 1 SERTM1 1 MPP1 1 PRELP 1 APC 1 DYNLL2 1 HELT 1 DPYSL5 1 STON2 1 N4BP2L2 1 FOXI1 1 FAM89A 1 MAP2K2 1 KMT2B 1 SCN3A 1 FECH 1 RP11-295P9.3 1 VSTM5 1 RIOK3 1 FHDC1 1 MYH11 1 ZNF514 1 ZFP36L1 1 TWF1 1 PRCP 1 GALT 1 ACTL7B 1 VMA21 1 CHID1 1 PEG10 1 C8orf76 1 CA4 1 NFKB1 1 TTC13 1 MS4A4A 1 AFF3 1 NKPD1 1 NBEAL1 1 PTCD3 1 SDR42E2 1 RXFP1 1 ZKSCAN2 1 KCNK13 1 PLEC 1 RNF103 1 PDILT 1 MBD3L1 1 SRP68 1 NRXN2 1 FAM47A 1 GPR155 1 INSM1 1 TBC1D14 1 KRTAP4-9 1 GALNT15 1 PLEKHM2 1 OR5AN1 1 GLYATL1 1 DPYSL4 1 FLVCR1 1 P4HTM 1 GZF1 1 ADAMTSL2 1 SRRM5 1 UMODL1 1 ZNF586 1 SCO1 1 SBF2 1 SLC39A14 1 ADAM12 1 C19orf24 1 OLAH 1 GNA12 1 FAM120C 1 LINC00969 1 SLC46A2 1 C11orf53 1 TRPM4 1 RIPK4 1 SNF8 1 SPAG5 1 ABCB6 1 SPDL1 1 COLEC12 1 ALS2 1 KCNF1 1 MBD5 1 C9orf173 1 MYOF 1 NOL12 1 ARHGAP36 1 PPP2R2C 1 AQP9 1 DCUN1D4 1 GLB1L3 1 CUL4A 1 VCP 1 HTR3A 1 ADGRD2 1 VCL 1 ADD2 1 MLANA 1 ROBO1 1 ZFP1 1 SHMT1 1 SRXN1 1 BRF2 1 POM121L9P 1 PSD 1 EIF4G1 1 MTPAP 1 NFIX 1 PRMT8 1 RUNX1T1 1 HBM 1 CASKIN1 1 SMOX 1 THUMPD1 1 KIAA1210 1 SERPINB12 1 C5orf15 1 UTP23 1 SORBS1 1 GPR132 1 SDK1 1 SOCS4 1 CASS4 1 ABCA10 1 DLGAP4 1 EGFL8 1 OR4Q2 1 SMIM24 1 SMAD5 1 OR6C1 1 RHBDF1 1 GBA 1 UBE2D3 1 NME5 1 ASH2L 1 GABRR3 1 USF2 1 TBC1D23 1 ABCC6 1 ESX1 1 FLT4 1 USP28 1 ASAH1 1 OS9 1 RTTN 1 DENND5B 1 CH17-140K24.8 1 RC3H2 1 MROH8 1 MBP 1 KIR2DL1 1 CTAGE15 1 GPN3 1 C9orf66 1 OPLAH 1 C4A 1 ADRA1B 1 ZNF750 1 VCAN 1 SLITRK2 1 SYNDIG1L 1 EPHB6 1 BCAT1 1 UBXN1 1 CEP350 1 WIBG 1 CSN1S1 1 ATP6V0D1 1 GPR37 1 ANXA11 1 SEMA4G 1 PRSS33 1 TTLL11 1 FOLR2 1 LIX1L 1 LINC01558 1 SNX1 1 NOL10 1 TRIM10 1 CD59 1 OR4N5 1 GLCE 1 P3H3 1 C9orf47 1 DPH2 1 POU2F2 1 XRN2 1 OVOL2 1 SNAI1 1 SEMA5B 1 ANKZF1 1 BCS1L 1 PILRA 1 PPM1J 1 THEG 1 ANK2 1 PRDM4 1 CHM 1 TRERF1 1 KRT23 1 HIAT1 1 GFM1 1 SNCG 1 DYNC1I1 1 CILP 1 LRAT 1 NCL 1 TAAR6 1 OR4C16 1 LAMA1 1 PRSS50 1 MKL2 1 EFNA1 1 PLA2G4E 1 CYP2A7 1 TDRD10 1 SLC17A9 1 KCNK16 1 HLA-DQA1 1 MR1 1 BCL2L1 1 TIAM1 1 CCL3L3 1 C8orf44-SGK3 1 DSCAML1 1 FAM150B 1 ITGA9 1 GBP5 1 MYT1L 1 OR1N2 1 AHNAK2 1 NPL 1 EFHC2 1 SLC30A1 1 CCDC132 1 CENPJ 1 OFD1 1 SGK223 1 SFTPD 1 FRMD4A 1 RGL1 1 RIN3 1 TMEM151A 1 NCF1 1 AK4 1 MAP9 1 CETN3 1 C8orf82 1 BRI3BP 1 KIAA1919 1 TSPAN31 1 VDAC2 1 GTF3C2 1 ACY3 1 PGM5 1 AMDHD2 1 G6PC3 1 LIN54 1 PTPRN 1 RP11-19E11.1 1 CDK9 1 RXFP4 1 UGT8 1 PRH1 1 PLAT 1 DEPDC1 1 GPAT2 1 ZMYM1 1 ASXL1 1 GPRIN2 1 P2RX4 1 HADH 1 ZNF217 1 KCNH3 1 SLC25A53 1 ROMO1 1 TNFAIP8 1 OSBPL7 1 MYLK4 1 SPATA5 1 CEBPB 1 MGST1 1 TRAF2 1 ZNF280B 1 TACR3 1 ELAC2 1 SH2D2A 1 CD8A 1 ZNF33A 1 FGF10 1 ZNF521 1 FADS3 1 PPP1R3C 1 DOC2A 1 PRDM9 1 MAP6 1 ARFGAP2 1 RAVER1 1 SKOR2 1 POLR3E 1 ZNF714 1 SYNPO2 1 PKLR 1 REXO1L1P 1 WDR45 1 ECHDC3 1 BTLA 1 SPRED3 1 SLC7A2 1 SHROOM4 1 DLX2 1 CR1 1 ANKS1A 1 ADH6 1 TAPBPL 1 SGPP1 1 MYH7B 1 MYNN 1 MYCBP2 1 ARL13B 1 C6 1 POLM 1 HDGFL1 1 PDCD6 1 CREBL2 1 SHROOM1 1 PARP4 1 FBXW12 1 ZBTB11 1 GREB1L 1 THBS3 1 NCAM1 1 JUNB 1 NDUFAF4 1 SHOX 1 COL14A1 1 SAMD9L 1 TRIQK 1 MYO1H 1 RORB 1 ICAM3 1 MIA 1 BAZ2B 1 POLQ 1 CCT6B 1 ALDH3B1 1 SIGLEC12 1 HIP1 1 KIAA2013 1 ZNF16 1 HHIPL2 1 ATP6V0A4 1 USP21 1 PMVK 1 ZNF645 1 NDUFC2-KCTD14 1 KLF12 1 CDC25B 1 PTCH2 1 NTF4 1 CD44 1 VANGL2 1 NTPCR 1 PPP1R8 1 NAGA 1 SATL1 1 IGSF11 1 GRM4 1 LCN12 1 CAPN1 1 GRIPAP1 1 RP11-385D13.1 1 PRM2 1 MECOM 1 DNAJC25 1 AMOTL1 1 RALGAPA2 1 ADAMTS7 1 USP29 1 DKK2 1 WDR6 1 GEMIN5 1 FREM1 1 CDH2 1 PROCA1 1 RRBP1 1 ARSG 1 OTOGL 1 RANBP17 1 CYFIP2 1 POMGNT1 1 VPS13C 1 SPOCK3 1 PAN2 1 TECR 1 AFF2 1 ADAMTS6 1 RBMXL1 1 RBBP5 1 MAX 1 MDK 1 RMND1 1 BTBD7 1 NDUFB4 1 ACER2 1 ID2 1 GPR174 1 CACNB1 1 DHRS9 1 C8orf34 1 LARP4B 1 MRGPRX1 1 HES1 1 MFF 1 ASPH 1 ANKRD13D 1 CCL4L1 1 EGR4 1 SLC10A1 1 LINC00657 1 MEF2D 1 RUNX2 1 ARMC2 1 EGLN2 1 SCYL3 1 SEC31B 1 NKAIN3 1 CPB1 1 ANKRD36B 1 PLK1 1 C20orf27 1 DYNC2LI1 1 ZNF367 1 CLDN17 1 GP9 1 OR14C36 1 ZNF408 1 RP4-800G7.2 1 MYRFL 1 LINC00602 1 LGI1 1 C11orf44 1 MTF2 1 SMYD4 1 RBMS1 1 GLP1R 1 TTC29 1 LRRC30 1 HGSNAT 1 SLC22A8 1 DRD1 1 PODXL 1 SCEL 1 HOXA5 1 FHOD1 1 ATF7IP2 1 HCG27 1 RAB3C 1 PCMTD1 1 RECQL4 1 STK32A 1 CATSPERB 1 NCKAP5L 1 DAP3 1 CDC37L1 1 FERMT3 1 PXT1 1 SUPT7L 1 TARDBP 1 F8 1 RP11-306O13.1 1 ABCG8 1 JPH4 1 CDH11 1 PCK2 1 CCDC93 1 ART5 1 KLHL21 1 SLC45A4 1 LRFN5 1 DNAJC9 1 TSPAN11 1 C1orf127 1 C6orf132 1 PIBF1 1 SIGLEC9 1 PAQR4 1 MON1A 1 MAGEC3 1 MEDAG 1 NOX3 1 CDA 1 AP3D1 1 MGAT1 1 POLR2A 1 OPHN1 1 SLX4 1 MFN2 1 KIAA1462 1 HIGD1A 1 CDH4 1 DCAF8 1 HERC6 1 OR52E6 1 SLC16A13 1 AC091565.1 1 DTX1 1 FGA 1 GTF2I 1 PROX2 1 ADAMTS16 1 LTBP2 1 ZNF655 1 KISS1 1 STPG1 1 IGKV4-1 1 PTGDS 1 ZNF718 1 RBM44 1 LSR 1 PAPSS2 1 FAM46A 1 PRR14L 1 KCNAB2 1 MLLT10 1 HSPD1 1 ACE 1 LRRC16B 1 FAM161A 1 CEACAM3 1 TLX2 1 ZNF384 1 TSTA3 1 L1CAM 1 AC023469.1 1 PNLIPRP1 1 GAB3 1 TCP1 1 RSPH3 1 TTC22 1 SLC25A30 1 SUN3 1 ZNF724P 1 SLC30A8 1 PCED1B 1 CLNK 1 GPR75 1 ARHGEF25 1 NLGN4Y 1 ANKRD34B 1 SCUBE3 1 CLTA 1 ARID2 1 POLR2H 1 NID1 1 GABRA4 1 CRBN 1 UHRF1BP1L 1 PTPRE 1 ANKMY1 1 PVRL1 1 SCIN 1 IGLJ6 1 MCM9 1 KIAA0020 1 RBSN 1 OR10W1 1 P2RX7 1 AK2 1 CDK17 1 KALRN 1 BEND6 1 CHKA 1 EFR3A 1 OMA1 1 ZNF26 1 DCLRE1CP1 1 SH3BP2 1 ARMC5 1 AMPD1 1 IL6R 1 DNAJB14 1 CCDC180 1 FAM222B 1 C19orf57 1 CHRNG 1 RASGRP4 1 NTN5 1 SPTAN1 1 CALR 1 SMAD3 1 RAB21 1 TNFAIP8L2 1 SLC3A2 1 REC8 1 UNC45A 1 PALB2 1 MGEA5 1 MYO1G 1 DTNB 1 CASC4 1 PLXDC2 1 CASP9 1 TTC9 1 TRIP6 1 RABEP2 1 CRB2 1 C18orf8 1 XDH 1 ZFYVE28 1 SNURF 1 RAB43 1 CDK4 1 ANAPC4 1 ZNF43 1 TMTC1 1 ZNF423 1 KCNIP4 1 CSK 1 CPLX2 1 ZNF189 1 UBA6 1 MTHFD1L 1 TTYH3 1 PLVAP 1 LUC7L 1 CKAP5 1 C12orf76 1 DENND4A 1 RP11-345F18.1 1 MAPRE2 1 NDUFA10 1 ZFYVE16 1 REPIN1 1 DGCR2 1 BMP5 1 CCDC84 1 AP000783.1 1 HLA-DMB 1 NPY5R 1 KIAA1958 1 KLHDC10 1 SRRM2 1 SLC35F6 1 SYP 1 HDGF 1 BLOC1S5-TXNDC5 1 NOL3 1 CNTN2 1 EHMT2 1 FAM160A1 1 TGFB1 1 SLC30A2 1 TRGC2 1 DPEP1 1 RALY 1 ANAPC7 1 SMARCAD1 1 DES 1 GALNTL6 1 PHRF1 1 ADORA2A 1 DHRS3 1 ITLN2 1 LSS 1 PAFAH2 1 ADAMTS18 1 TAF4B 1 ZNF268 1 TMEM70 1 ECT2L 1 MFAP5 1 MYO5A 1 KRT17P1 1 GPX1 1 ADGRV1 1 SUDS3 1 UBALD1 1 STKLD1 1 SH3KBP1 1 BRMS1L 1 APRT 1 SDHAF2 1 CTSD 1 PARP1 1 PIWIL3 1 AP3B2 1 TUBA3E 1 RPL19 1 HPS6 1 ANO6 1 NAT10 1 RAB12 1 PLCXD2 1 RAD50 1 PSEN1 1 ANKDD1A 1 ITGA2B 1 RPGRIP1L 1 CPNE9 1 GFM2 1 SLC4A1AP 1 ELN 1 CDKN2AIP 1 TMEM51 1 KDM5A 1 GLRX 1 VPS72 1 OR2A5 1 JPH2 1 FERD3L 1 CREBZF 1 DBT 1 LAMP5 1 MS4A3 1 ADGB 1 PPP1R3A 1 UGCG 1 RP11-645C24.5 1 MTMR2 1 CLEC4E 1 RNF207 1 DMPK 1 FLRT1 1 GCNT2 1 CAPG 1 CHMP4B 1 CCDC57 1 CYYR1 1 KATNB1 1 PTH1R 1 CDC25C 1 FBXO10 1 PLEKHA8P1 1 ENY2 1 SUPT20HL2 1 CD37 1 CCDC13 1 VPS37C 1 TRIM27 1 SLC9A5 1 SHPRH 1 RHOB 1 CLK3 1 STAT3 1 NBAS 1 SCAMP3 1 TAZ 1 CCR3 1 SMARCD3 1 HBG1 1 NMNAT1 1 SLC17A7 1 MYPN 1 APOBEC1 1 MTFR2 1 MLH1 1 CD80 1 FAM151A 1 WDR91 1 GLRA1 1 IREB2 1 TCEB3 1 TUBGCP2 1 PIAS3 1 ATXN3 1 SEC14L2 1 OR9Q2 1 SNORD114-1 1 FAM183B 1 CARD6 1 RNF122 1 ANXA5 1 PTGES2 1 OSGIN1 1 SIGLECL1 1 IKZF1 1 CROCC 1 RNF123 1 FUT6 1 IFT140 1 FAM187B 1 EVPL 1 VWA8 1 MAPK15 1 JAZF1-AS1 1 TREML2 1 ANKRD66 1 CNGA3 1 ATF4 1 FAM205BP 1 ACAP3 1 RP11-2H3.7 1 CXorf21 1 FBXO43 1 WDR38 1 TRABD2A 1 SMO 1 THEGL 1 TSPY1 1 SPINK14 1 TKT 1 PCDHA2 1 SOX6 1 NGRN 1 PAK3 1 GORASP2 1 SLC2A10 1 THOC5 1 TTC24 1 ACO1 1 C20orf195 1 MMP7 1 RP11-87M18.2 1 RAB6A 1 NIPAL4 1 SORBS3 1 KLHDC7A 1 TCTN1 1 ZNF707 1 CCDC25 1 LHX1 1 PKN3 1 OR4D9 1 RFK 1 ZNF114 1 ESYT1 1 ENPP3 1 SAP30L 1 GRN 1 ZBED8 1 PODN 1 RHOBTB1 1 ACSM2A 1 OTOL1 1 GPC1 1 KRTAP11-1 1 WBP1 1 ERMAP 1 ISX 1 CCM2L 1 SFT2D1 1 GPR151 1 DNAH8 1 SLC26A9 1 NDUFV2 1 SEH1L 1 ZNF467 1 HPS3 1 MRPL10 1 MRPL44 1 PTGES 1 IGLV4-69 1 PRAMEF1 1 ATP8B3 1 OSR1 1 R3HDML 1 SLC7A3 1 CYP1A1 1 ZNF143 1 ZNF665 1 TOMM5 1 ZNF197 1 DNAJC7 1 TRIM6 1 IFT52 1 GATA6 1 PET117 1 ZNF230 1 BCO2 1 ACAD9 1 C14orf80 1 FAM89B 1 SLC35G3 1 CRY2 1 NBPF9 1 MNX1 1 SLC29A2 1 IGSF10 1 GPR137B 1 PHF8 1 AZIN2 1 LRP4 1 MORN1 1 MADD 1 PYGL 1 KDM4B 1 CBX3 1 FAM186A 1 FRMPD3 1 DDX1 1 SPATA31A1 1 SLC34A3 1 E2F2 1 MCHR1 1 PRPF3 1 TUBB6 1 FERMT2 1 SNHG5 1 ZCCHC24 1 RSPO1 1 DNAJB2 1 PIK3CB 1 TFE3 1 ZNF583 1 C7orf43 1 ZNF671 1 ABHD11 1 POMT1 1 HES2 1 RPL35 1 CGB7 1 PSMA4 1 ZNF582 1 NME8 1 CCSER2 1 FAM153B 1 C5orf38 1 STRA6 1 STXBP3 1 ZNF559-ZNF177 1 OR6C68 1 PCDHA6 1 GOLGA4 1 BCAR3 1 TRMT6 1 PDZRN4 1 PTPRO 1 EIF4A1 1 SAMD7 1 NAAA 1 CELF4 1 DNAJC19 1 RASSF10 1 DVL3 1 ST18 1 PAGR1 1 TFDP2 1 FAHD1 1 KRT84 1 GEMIN4 1 IGHG4 1 RMDN1 1 VEPH1 1 HYAL4 1 MICALL1 1 CCDC15 1 ZEB2 1 DDX20 1 DIAPH2 1 MINPP1 1 GSDMD 1 FN1 1 R3HDM1 1 POFUT1 1 AFM 1 JRK 1 PER1 1 FCRL3 1 SLC17A3 1 ALDH1A1 1 LPIN3 1 ARHGAP35 1 TRAC 1 CCNE1 1 ANKRD46 1 TONSL 1 HK1 1 IGHG1 1 RASEF 1 ZNF227 1 ENG 1 FITM1 1 COMT 1 EGFR 1 AQP2 1 UGT1A1 1 CPE 1 TCP11L1 1 MAGEB3 1 EXOC5 1 GFOD1 1 CD320 1 OR6M1 1 GFY 1 C5orf60 1 DGKI 1 RASGEF1B 1 ERLEC1 1 EMC9 1 TBX3 1 PLD2 1 IRAK1 1 WNT9B 1 PDAP1 1 NXNL1 1 TRAP1 1 DYRK2 1 DNAI2 1 INO80 1 KRTAP5-11 1 RP11-551L14.1 1 JPH3 1 NUF2 1 DDAH1 1 FUS 1 GPC3 1 CTTN 1 IRX3 1 CR2 1 CDC42SE1 1 FUT7 1 CELP 1 CD180 1 ZNF85 1 PTPN2 1 DHRS4 1 SYT5 1 SRSF7 1 MTMR11 1 EML5 1 PKD2 1 BAIAP2 1 ZNF736 1 VAMP3 1 DOK4 1 VNN1 1 CHRNB3 1 FBXO25 1 DDX23 1 B3GNT4 1 RAB4B 1 ATAD3B 1 TICAM1 1 CEP57 1 TIMM23B 1 TUBB8P7 1 SPC24 1 AMELX 1 ZDHHC11B 1 PIWIL2 1 MIER1 1 ATXN7L3B 1 ASZ1 1 COL6A3 1 KRTAP15-1 1 ZNF41 1 SLC45A2 1 QARS 1 ACBD3 1 KPNA5 1 MGAM 1 TAS2R19 1 MTBP 1 WDR54 1 UBE2M 1 NTNG1 1 NCOR2 1 GTSE1 1 RPL10A 1 HNRNPUL2 1 HR 1 OR5M3 1 CPLX4 1 PDSS2 1 UBAC1 1 TSPAN19 1 OSBPL8 1 CYC1 1 AVPR1B 1 ITIH1 1 RP11-3P17.4 1 USO1 1 PMS2 1 SHPK 1 ECEL1 1 TRPV4 1 MARCH8 1 GULP1 1 AGL 1 UBA3 1 DLGAP3 1 RP11-707O23.5 1 ITGA2 1 REV3L 1 ZC3H6 1 ZNF286B 1 DAPK2 1 CNTNAP5 1 SHROOM2 1 TUBGCP6 1 TTC38 1 TRA2B 1 CHST9 1 CRISPLD2 1 MAGEA12 1 BTBD19 1 OPA1 1 DAAM1 1 COCH 1 HYPK 1 CCDC14 1 TSSC1 1 MOB3A 1 SIX4 1 SENP1 1 SLITRK5 1 MICU3 1 SLC19A2 1 EEF1E1 1 MICU1 1 PTGDR2 1 GNA14 1 SWAP70 1 DZIP1 1 DIO3 1 OPRM1 1 PHTF2 1 MAP4K1 1 CDH24 1 IL6ST 1 ZIM2 1 C19orf44 1 CD28 1 RPL24 1 ZAP70 1 SLC41A1 1 SIK2 1 HIPK1 1 LRG1 1 IGKV1-5 1 SYT7 1 FCN3 1 EIF3B 1 CCL19 1 C15orf53 1 SF3A2 1 OR6C74 1 ATF7 1 CBFA2T3 1 GPD1 1 HECTD1 1 FAM57B 1 BSCL2 1 GOLGA6L10 1 SP1 1 RP11-240B13.2 1 UBE4B 1 NDN 1 ANGPT4 1 ZBBX 1 PRDX2 1 HEPACAM2 1 HUWE1 1 SARM1 1 PUM1 1 AZGP1 1 DNAI1 1 DCAF12 1 POLR1E 1 XYLB 1 NODAL 1 PXMP4 1 FSCN3 1 FAM160A2 1 MB 1 SUSD2 1 TCF3 1 CCNT1 1 PPP1R11 1 AP3B1 1 PRELID1 1 OR2B6 1 DNAJC8 1 ABCD1 1 ESYT3 1 RPL23A 1 OR5D16 1 ZFHX2 1 PHC1 1 ZDHHC2 1 RAET1E 1 PAK6 1 CYP2U1 1 PCDHGB1 1 KIAA1217 1 PSMD12 1 NAA25 1 TIAM2 1 CYB5R3 1 TTC23L 1 KRTAP19-3 1 KCNQ5 1 E2F1 1 FAM8A1 1 GPR68 1 RAB28 1 BUB1B 1 SEMA6C 1 T 1 RNPEPL1 1 HLA-DRA 1 FER 1 CD84 1 TRAIP 1 CRISP2 1 ANKRD32 1 NOMO1 1 CTC-231O11.1 1 ESPL1 1 TTC19 1 C3orf84 1 SPIN2B 1 GRINA 1 BLVRB 1 CSF3 1 CA12 1 HSPB1 1 AMY2B 1 ADH1A 1 ZNF646 1 PCDHA13 1 BBS9 1 GFPT2 1 ETFB 1 MLPH 1 GLYATL3 1 DDX11 1 ELAVL4 1 LINC00115 1 HDAC10 1 ASB4 1 KIFAP3 1 ICAM5 1 KDM3B 1 BAHD1 1 CTSC 1 FPGT-TNNI3K 1 ZFYVE1 1 SH3BGRL3 1 METAP2 1 KCNJ12 1 KIF2A 1 ALDH4A1 1 PRM1 1 ASL 1 CYP17A1 1 GAPVD1 1 SLC13A5 1 RAB3GAP2 1 CACHD1 1 GZMA 1 ACRBP 1 UGT1A4 1 CDC42BPB 1 KIAA1429 1 DIS3L2 1 ALB 1 NABP2 1 TTC33 1 FABP3 1 RABGAP1 1 METTL21B 1 DSN1 1 pk 1 ZNF491 1 SNX31 1 BIRC2 1 CXorf57 1 ERAL1 1 ZNF556 1 SCN8A 1 SNX32 1 PDE4D 1 HOXD13 1 ARRDC4 1 SLC5A3 1 MARCH2 1 TRPC4 1 SLC6A14 1 CCDC47 1 TOX 1 CCDC159 1 FBXO17 1 FERMT1 1 NUP205 1 HMMR 1 TMEM8C 1 IL17RA 1 FLCN 1 APPL1 1 PHLPP1 1 TSPAN32 1 AP2M1 1 DNPH1 1 GPR157 1 C11orf45 1 ZNF540 1 NLRP11 1 TRIB2 1 C3orf49 1 CNNM3 1 PPP1R27 1 CELSR2 1 PLIN4 1 SLC6A9 1 GDNF 1 PLA2G5 1 LTBP4 1 NPAS3 1 ARMCX4 1 TXNRD3 1 POGZ 1 PELP1 1 LSG1 1 OR1A2 1 OSGIN2 1 GPR149 1 ZNF836 1 RFX3 1 HOXC6 1 ARHGAP29 1 ARHGDIG 1 UBE3C 1 ABTB1 1 CRTAM 1 ABCC8 1 FILIP1 1 C1QL2 1 CPNE7 1 LINGO1 1 LTN1 1 ZNF222 1 KLRC4 1 PIGV 1 TRIM58 1 IGLV4-3 1 FAM167A 1 ELFN1 1 ATP5I 1 HCAR3 1 TMEM26 1 BTG4 1 CSE1L 1 PTPRS 1 RHOF 1 SLU7 1 KRT74 1 C9orf114 1 CLCA2 1 RBL1 1 SIPA1 1 MSTO1 1 CACNA1E 1 PSTPIP1 1 KIF5C 1 ZNF627 1 RPS6KB2 1 CRELD1 1 MROH2A 1 SLC16A10 1 LY6H 1 DCBLD1 1 CHRD 1 UBR7 1 PLG 1 FNIP1 1 WBSCR28 1 OR5I1 1 ECD 1 NCAM2 1 RAB4A 1 GART 1 RAF1 1 PARS2 1 CNOT7 1 HEY1 1 MED30 1 IL32 1 CCDC146 1 TBC1D10A 1 VSTM2A 1 C11orf96 1 GRAMD1C 1 PPP1R26 1 AP1M1 1 ATP2A1 1 LRRC28 1 HOXC5 1 ZBTB49 1 TYK2 1 PIAS4 1 SLC12A3 1 FBXO38 1 TMEM184B 1 CSNK1D 1 KIF12 1 CSF2RA 1 MPDU1 1 PLCL2 1 MRGPRG 1 ABCC11 1 ATG4B 1 ZNF829 1 TMUB1 1 DCAF15 1 ATXN7L3 1 S100A1 1 LYN 1 ATP8A1 1 PDX1 1 LMOD1 1 PPP6R2 1 FNTA 1 IMMP2L 1 CCDC106 1 PCSK7 1 ANK1 1 IL17RD 1 OR2L3 1 PHLDA1 1 MUTYH 1 CCDC65 1 ABCA3 1 GSTA2 1 KIAA1875 1 SLC16A4 1 NUFIP2 1 BCL11A 1 APTX 1 BMX 1 SMAD4 1 HERC3 1 UNC13A 1 TMEM208 1 GSTO1 1 COMMD6 1 ATF7IP 1 HERC1 1 MTRF1L 1 RBBP7 1 ARHGEF17 1 DBP 1 TEAD1 1 TTC39B 1 EPB41L1 1 DCLRE1B 1 LIPC 1 INO80D 1 TBC1D2 1 OTUD5 1 SLC9A4 1 IGSF1 1 CTCF 1 ZNF224 1 MCTP1 1 TCP10L 1 OR5K2 1 NDST2 1 ZFAT 1 ZFC3H1 1 FTCD 1 CLCA4 1 KIF1A 1 ARHGEF18 1 LTBP1 1 TDP1 1 SBK1 1 ADGRE5 1 USP17L1 1 HIST1H3A 1 NTF3 1 STK10 1 ZNF140 1 MEGF11 1 SFTPB 1 STX17 1 FAM21C 1 SLC27A3 1 DKFZp313A047 1 PRPF39 1 HERC2P3 1 RMI1 1 CACNA1D 1 AKAP3 1 LGI4 1 MROH1 1 KLB 1 C12orf75 1 PRAF2 1 IL17C 1 ENPP1 1 POMT2 1 GNAI1 1 NUDT13 1 ADGRG2 1 TSN 1 TPR 1 TPSD1 1 CHAF1B 1 RALBP1 1 DUSP28 1 C2orf81 1 HCAR2 1 IL1RAP 1 MESDC1 1 ZBTB46 1 OGT 1 COQ9 1 TOMM20 1 TSNARE1 1 TET2 1 PPP2R3C 1 ZSWIM3 1 DTWD1 1 COBLL1 1 PDE3B 1 GPR26 1 FCAR 1 TPX2 1 WDR63 1 KLHL40 1 MAP3K13 1 ADH4 1 C3P1 1 SLC5A5 1 PTCHD4 1 RPL13AP20 1 UBE2V2 1 HEXIM1 1 PRMT3 1 ATXN3L 1 TIGD6 1 SUCLG2 1 TP73 1 ABCA8 1 HSPBP1 1 TBX19 1 ERCC6L2 1 SRSF10 1 PEX16 1 OR1M1 1 MADCAM1 1 LILRA6 1 PROX1 1 RP1L1 1 FAM177B 1 NGDN 1 MRPL3 1 C16orf96 1 SERPINB4 1 ZNF346 1 KCNC2 1 SMIM9 1 FZD9 1 DCAKD 1 ABT1 1 ZNF502 1 POTEC 1 ZC3HAV1 1 PKD1L3 1 CAMSAP1 1 RCN1 1 GRIP2 1 TXNL4A 1 PSMC6 1 FAM214B 1 C2orf78 1 SLC25A29 1 ALDOA 1 TFAM 1 MMP15 1 MXD3 1 MYLK3 1 ZNF341 1 ZNF600 1 NXF5 1 LAMC3 1 CHP2 1 SLC35G2 1 ARHGDIA 1 GNAI3 1 IGSF8 1 RGS5 1 LPCAT4 1 NYAP2 1 ACOX2 1 EFCC1 1 SFMBT1 1 EDIL3 1 GFRA3 1 NBL1 1 VAV3 1 OGFR 1 PLIN2 1 TMEM254 1 KAL1 1 MMP24 1 MAGOH 1 CEP162 1 DYRK1A 1 SPNS2 1 ZNF446 1 MAP2K1 1 AMY2A 1 TLDC1 1 IGF2BP1 1 DOLK 1 SLTM 1 MARVELD3 1 TRNT1 1 RP11-350F16.2 1 PCDHA1 1 C1orf123 1 RASD1 1 USP22 1 CENPV 1 CACNG7 1 GRM5 1 ANKRD24 1 ACTRT3 1 ATP9A 1 ISLR2 1 A1CF 1 KPNB1 1 PCDHB14 1 CACNB4 1 ZCCHC2 1 NRAP 1 PIK3R4 1 BMP2K 1 DPYSL3 1 LTBP3 1 TSHZ3 1 CYP7B1 1 ACHE 1 ZNF782 1 PPP1R10 1 NPIPA7 1 MAOB 1 MMP9 1 UGT2B10 1 PLEKHA4 1 TIA1 1 PP2D1 1 SERPINB6 1 EIF4E 1 NOM1 1 PTRF 1 RAB37 1 ZMYM5 1 DLG1 1 AC073869.2 1 ZNF670 1 FGF3 1 B4GALT4 1 NCOA5 1 FAM206A 1 CD68 1 RNPEP 1 KIAA0922 1 CTPS1 1 HIPK2 1 TTLL4 1 DSC1 1 STK16 1 TMA16 1 CNTNAP4 1 ABI3 1 LRRC8B 1 CPNE2 1 FMNL2 1 FFAR4 1 GPR162 1 RERE 1 SH3GL1 1 ADAM2 1 MIR124-2HG 1 RAPGEFL1 1 FAM84A 1 MMAA 1 METTL15 1 DTD2 1 DLG4 1 PCMTD2 1 DENND3 1 SYN1 1 HEATR1 1 CSNK1G1 1 PFDN2 1 IRX4 1 GGT2 1 XXbac-BPG308J9.3 1 TLN2 1 SCIMP 1 ADCK5 1 HNRNPAB 1 DGKK 1 OR2A2 1 LRRC6 1 TMEM200A 1 TRPM6 1 OXA1L 1 TNFRSF4 1 PCDHGA6 1 C14orf119 1 SERPINB3 1 PCDHB16 1 FAM200A 1 TOP2B 1 HSD17B14 1 SLC6A16 1 EIF2B4 1 FLRT2 1 HEATR5B 1 PJA2 1 SUPV3L1 1 ARHGEF10 1 IPO9 1 KSR1 1 TMEM106B 1 IFT22 1 LMBR1 1 ABCD4 1 EPS8L2 1 CTSS 1 TMEM86A 1 FEV 1 TTLL13P 1 EZH1 1 OR5AS1 1 PABPC4L 1 CCDC108 1 CALML6 1 LRRTM3 1 SRCIN1 1 ICE2 1 BICD2 1 SLC25A48 1 MKLN1 1 HS6ST3 1 MOB4 1 NCOA6 1 PSMB4 1 ZBED1 1 TRIM14 1 ABCD2 1 TBKBP1 1 AMER3 1 NFE2L1 1 EEF1A1 1 FAM155B 1 CISH 1 WFS1 1 ZNF324B 1 ATP8B2 1 NHLRC1 1 AGRN 1 ADGRB1 1 PLEKHG1 1 FAM114A2 1 DPT 1 VWF 1 CXorf40A 1 RBFOX3 1 RHOC 1 MAGEB6P1 1 SLC7A1 1 DIABLO 1 ARSF 1 CNGA2 1 PLCD1 1 PRSS36 1 RPN2 1 POFUT2 1 YWHAQ 1 NCR2 1 C17orf49 1 ZKSCAN1 1 CRP 1 KIAA0368 1 IGF1R 1 GLRA3 1 UTP14A 1 SAFB 1 ARVCF 1 C8orf31 1 MYOZ3 1 TPTE 1 ZNF599 1 EMILIN3 1 TBC1D24 1 ACAP1 1 EPB41L3 1 C20orf203 1 FAM188B 1 GPAM 1 HCN2 1 PEG3 1 HELLS 1 TLX3 1 GCNT6 1 PLEKHG3 1 HTATSF1 1 PCDHA12 1 RP11-290F24.3 1 ACSM4 1 STARD9 1 CPT1A 1 OR56A3 1 RAB7A 1 OR11L1 1 MPI 1 ELP3 1 RTF1 1 TMEM181 1 LRRC56 1 FARP1 1 SREBF2 1 NIPAL3 1 TCN1 1 CPEB4 1 SLC35D2 1 TRIM47 1 CALCOCO2 1 ABCC1 1 C9orf50 1 UBA2 1 N4BP2L1 1 STAB2 1 GALC 1 ACAP2 1 MMACHC 1 PPP1R13B 1 MMAB 1 IDH3B 1 RBPMS2 1 HEXA 1 LAMA3 1 NACC1 1 PLCZ1 1 C11orf68 1 STAT6 1 CFTR 1 GPAA1 1 ENO4 1 CRTC3 1 IGFBP4 1 MYDGF 1 IRAK2 1 OR2B2 1 FAM210B 1 CECR1 1 HS3ST2 1 POSTN 1 DUOX2 1 PRR29 1 RPAIN 1 SLC22A4 1 MITF 1 SSX2IP 1 PKM 1 EEF1G 1 FSTL1 1 LAMA5 1 HP1BP3 1 SDC1 1 ADAMTSL3 1 PHYKPL 1 HSP90B1 1 C1QTNF4 1 KCNJ4 1 CTC1 1 UBAP2L 1 GRB2 1 MAT1A 1 MRPL4 1 SHD 1 CPNE6 1 ZNF527 1 SERF2 1 LCN6 1 SGPL1 1 RGN 1 GDF10 1 AVL9 1 UMOD 1 GAMT 1 LIMD2 1 ZNF581 1 TRIM64C 1 UBE2O 1 B3GALT4 1 TRIM26 1 ZNF395 1 FBXO46 1 SDSL 1 ADGRA3 1 NLRP5 1 BLZF1 1 KIAA0513 1 SCN7A 1 IFT88 1 PRKX 1 KLF3-AS1 1 SLC1A6 1 DDX58 1 AMPD3 1 ACBD4 1 EPHA5 1 ITSN1 1 ADM 1 MAPKAPK3 1 TCHHL1 1 ZNF248 1 CUL5 1 B3GNT5 1 SRRM3 1 NLRP3 1 CAPN12 1 CFAP44 1 RP11-774O3.3 1 PPP1R1C 1 C1GALT1 1 NRCAM 1 SLC28A3 1 USP48 1 VARS 1 SH3RF2 1 SLC39A1 1 GABRB1 1 FAM83C 1 PLD5 1 GRK5 1 DZANK1 1 GANAB 1 SEMA3C 1 HNRNPCL1 1 OR4K2 1 NFIA 1 CCNYL2 1 FKBP1B 1 GPX5 1 ADNP2 1 SFI1 1 NVL 1 TAX1BP1 1 ZSWIM5 1 KCTD18 1 PCSK5 1 DHFRL1 1 HLF 1 ZNF526 1 IQCE 1 SLC17A1 1 TMEM41A 1 LAMC2 1 C4orf33 1 SLC25A27 1 CORIN 1 FUZ 1 FXYD6 1 ARHGAP31 1 DCP1B 1 TNS1 1 TNFRSF1B 1 HDAC4 1 TRMU 1 KRTAP4-8 1 IQCJ-SCHIP1 1 PDLIM3 1 ANKH 1 KRT33B 1 NLRC3 1 UBXN2A 1 IGSF5 1 SV2B 1 GP5 1 EXT2 1 OR6A2 1 IGF1 1 AC007792.1 1 PCSK2 1 PPP1R12C 1 KIAA1211 1 LRRC72 1 SCYL1 1 PNPLA7 1 PAX6 1 VWA5B2 1 ATP1A2 1 DHX15 1 C21orf2 1 PPP3CA 1 KLRG2 1 IRF1 1 HOOK2 1 SEPT8 1 TAB2 1 LINGO4 1 ADAMTS3 1 CCDC27 1 RRP12 1 NPM1 1 CMBL 1 NOG 1 ZIM3 1 HMGN2 1 BCL9L 1 ZGPAT 1 LONP1 1 CFH 1 RNF14 1 NOS2 1 PLXNA2 1 MINK1 1 KIAA1683 1 ANKS6 1 KLHL10 1 SF3A1 1 CLCN3 1 NTRK3 1 SNX29 1 PGBD1 1 SLC35G4 1 CERS5 1 RXRB 1 KCNC4 1 ZBED9 1 GLG1 1 PARP8 1 SLC9A7P1 1 CHEK2 1 RBM22 1 MVP 1 SREK1IP1 1 SRSF12 1 FZD5 1 NT5DC1 1 EFCAB8 1 AFF1 1 COL26A1 1 BCAS1 1 RP11-178C3.1 1 KIAA1468 1 MAML1 1 NGFR 1 PRRC2A 1 EYA4 1 OR13H1 1 CEACAM1 1 FAM120B 1 WDR1 1 CNOT8 1 BFAR 1 PCNX 1 LRIG1 1 BMP7 1 CLCN2 1 C5orf52 1 TOX4 1 CDIPT 1 MIR522 1 TTC21A 1 AARS 1 NEURL2 1 LSM12 1 SLC2A9 1 RSPO2 1 CHD7 1 LATS1 1 RGS9 1 KIDINS220 1 SLC35A2 1 PTGFR 1 PCDH11X 1 TCTN3 1 ZNF626 1 CATSPERG 1 CNST 1 BCORL1 1 SLIT3 1 DUOX1 1 HNRNPM 1 CTAGE1 1 KLK13 1 MBD2 1 TSNAXIP1 1 KRT32 1 CTR9 1 SIGLEC6 1 HOXB1 1 PCGF1 1 LINS 1 NEK5 1 OR10H1 1 RP11-166B2.1 1 TRIM23 1 ALKBH4 1 LOXL4 1 A4GNT 1 NPY1R 1 GRB10 1 CYP26B1 1 SPACA1 1 MMP20 1 CADM2 1 C1orf87 1 BAZ1A 1 MLXIPL 1 CHST6 1 PRPF40B 1 ATXN10 1 SORCS2 1 SPATA31D1 1 CNP 1 IGHV1-69 1 SOS2 1 CDIP1 1 SLC5A2 1 BTBD10 1 MTMR9 1 STK31 1 DBN1 1 VPS39 1 ALX4 1 XK 1 LHX6 1 PARP16 1 CAMSAP2 1 PA2G4 1 EIF5B 1 CCDC63 1 SLCO2A1 1 ZSCAN4 1 FCRLB 1 XRCC5 1 DHX16 1 PDCD2 1 LRRN4 1 RALGPS1 1 CASD1 1 MRPL27 1 ANKFN1 1 NASP 1 ALKBH7 1 LARP7 1 LINC00470 1 ADTRP 1 FOXD4 1 SPARCL1 1 FAM126B 1 ZNF468 1 TACR2 1 RPS14 1 PM20D2 1 PCDHGA5 1 OAT 1 BECN1 1 ZBED4 1 LRSAM1 1 SLC25A13 1 GSTO2 1 HAUS2 1 HUS1 1 NCOA2 1 PANK3 1 PLD1 1 PSIP1 1 BUD13 1 ZCCHC17 1 PCBP3 1 SLC22A24 1 UBN1 1 NT5DC3 1 PPIL1 1 PHOX2B 1 C14orf159 1 FZD6 1 KIAA0895 1 RANBP6 1 EPYC 1 NOTCH4 1 EYA3 1 MUC1 1 MARK2 1 MAGEB1 1 RMND5B 1 EMC1 1 ITGB7 1 SLCO1A2 1 INTS8 1 CIPC 1 SNAP29 1 SCFD1 1 RNF20 1 ZNF296 1 ATG3 1 PLCH1 1 NTAN1 1 SLC27A6 1 ZNF430 1 DNM1L 1 ARL4C 1 FSD1L 1 YWHAB 1 EFCAB6 1 SIRT7 1 FLNA 1 THBD 1 MTPN 1 ARID4B 1 PRAMEF4 1 OR7A5 1 HMBOX1 1 LGALS9 1 AGPAT3 1 KRTAP19-2 1 CFAP52 1 SCGB3A2 1 ADGRG7 1 TRPV2 1 TMTC2 1 RP11-32B5.8 1 XPO5 1 SELE 1 PLA2G4D 1 CEP290 1 F10 1 PTPN4 1 CYP4B1 1 ABCC4 1 AXL 1 CCDC90B 1 GTPBP4 1 ANKRD34C 1 BOP1 1 SKI 1 ORM2 1 ANO7 1 EPHB4 1 DPPA2 1 RAPH1 1 CROT 1 LAMC1 1 DPP4 1 ATP12A 1 BCL2L14 1 CDHR5 1 ZNF518B 1 KRT8 1 GPR158 1 STAG2 1 ZNF184 1 CYP2D6 1 TRPV5 1 USP46 1 OR5AU1 1 MBD1 1 FGB 1 PRRG2 1 DPCD 1 RPARP-AS1 1 TTLL9 1 PRKCQ 1 TNFRSF25 1 NRP1 1 ZNF705D 1 ZNF624 1 STK25 1 PLEKHG2 1 PALD1 1 LYSMD2 1 RP11-115F18.1 1 CNTNAP3 1 SLC4A3 1 FASTK 1 MAPK14 1 RAPGEF3 1 PEPD 1 PAM 1 TMEM61 1 FXR1 1 NEK10 1 CC2D1A 1 C19orf53 1 ATPIF1 1 HOXA2 1 SLC9A9 1 ANP32A 1 HLA-V 1 PLCB1 1 RPS6KA1 1 SLC22A23 1 MPDZ 1 TNMD 1 PTPN13 1 GPLD1 1 C19orf25 1 FAM135B 1 TNFAIP8L3 1 CSTF2T 1 RUFY2 1 PSD3 1 SNAPC1 1 TACC1 1 SHANK1 1 ARHGAP12 1 RPS3A 1 DOK2 1 AGAP1 1 SLC35B1 1 FEM1B 1 ADAT1 1 ZNF511 1 LUC7L3 1 SPINK4 1 FASTKD3 1 F3 1 GGT5 1 MMRN1 1 RDH5 1 TUBB2A 1 LPIN1 1 SUGT1 1 DND1 1 CACNA2D1 1 TMEM252 1 ATP2B2 1 GADD45A 1 SLC37A1 1 SEMA4B 1 ARHGAP4 1 EFHC1 1 CYTH3 1 CIR1 1 OR51J1 1 HEY2 1 NPTXR 1 E2F6 1 SPATS1 1 SLFN12L 1 PER3 1 IGDCC3 1 ANKRD35 1 CECR5 1 BCDIN3D 1 SYN3 1 PHF2 1 FANCA 1 TSGA13 1 L3HYPDH 1 MIIP 1 PTPN3 1 BTNL9 1 SLC6A12 1 SLC16A9 1 PEX26 1 CAMK1 1 UNG 1 HCFC1 1 CELF5 1 TMEM169 1 XKR7 1 CACNG6 1 LIPH 1 ZNF462 1 SLC25A39 1 CD2 1 CKAP2L 1 PTGS1 1 DNMBP 1 DCUN1D1 1 LRP5L 1 GNRHR 1 SPAG8 1 HSP90AA4P 1 LDB1 1 AC011525.2 1 KCNK5 1 CATSPER1 1 EMILIN1 1 C2CD5 1 R3HDM2 1 POLR1C 1 SWSAP1 1 ARHGEF35 1 ITGA1 1 FAM170B 1 RPL10 1 IL10RA 1 AQP8 1 FAM53A 1 CACNA2D3 1 CAV1 1 FAF1 1 GABBR1 1 MAGOHB 1 C6orf136 1 PNMA3 1 MFSD3 1 SIK3 1 ARAP3 1 AGBL1 1 EDEM2 1 MARVELD1 1 TMEM184A 1 DSCR3 1 APOC2 1 MAML2 1 BAG6 1 ZNF318 1 CCDC79 1 ATG7 1 FANCG 1 KRT37 1 KLHL11 1 NBN 1 GALNS 1 CTC-490E21.13 1 MYL1 1 RANBP10 1 LRRC16A 1 PPHLN1 1 UTP20 1 SLITRK1 1 SIKE1 1 OAZ3 1 CYP4F3 1 ADPRHL2 1 CYTH2 1 NAA60 1 RP11-331D5.2 1 CCDC7 1 MSLNL 1 NLRP6 1 FGFR1OP2 1 F5 1 BMP3 1 DUXA 1 CLU 1 IRF2BP1 1 CYGB 1 TRAF3IP3 1 COL15A1 1 IFT80 1 ICE1 1 AC124312.1 1 RBBP9 1 MBLAC2 1 OR8B12 1 FAM204A 1 DR1 1 CDHR4 1 FAM104A 1 VEGFA 1 SCAF1 1 TAF13 1 PRKACG 1 RPRD1B 1 AP5B1 1 CARS2 1 PRDM5 1 RBM15 1 GLDC 1 SAMM50 1 OR9K2 1 OXSM 1 ASPN 1 GRK7 1 RTN4RL2 1 CD33 1 RP11-195F19.5 1 PEX3 1 HIBADH 1 ZC3H7B 1 PRR27 1 IL10 1 ZPBP 1 CCDC150 1 ADAP2 1 RPS6KA4 1 VNN2 1 HS3ST4 1 CASP4 1 ZC3H14 1 DNAAF1 1 SKP1 1 FTSJ3 1 PCDHGA8 1 ISG20L2 1 MAPKBP1 1 PPP2CA 1 STARD5 1 EXOSC9 1 ACTN3 1 MXD4 1 DPY19L3 1 GDF5 1 OR13D1 1 SMG7 1 GP2 1 KIF19 1 MYBPC2 1 SSTR4 1 SERPINI2 1 PSMD1 1 PRKCZ 1 FOXO1 1 OR5L1 1 ANKRD31 1 ZDHHC20 1 ZFAND1 1 AGBL2 1 CLASRP 1 TECTA 1 FBXL17 1 ALLC 1 IL2RG 1 ANO2 1 POLA1 1 NDUFAF7 1 APH1A 1 HAS1 1 OAZ1 1 B3GALT5 1 VN1R1 1 PSG4 1 UTS2R 1 EPHX3 1 SMCR8 1 LLGL1 1 CABP7 1 SH3TC2 1 LRIT2 1 DARS2 1 JAKMIP1 1 CCDC91 1 PSG8 1 OGFOD2 1 DIS3 1 REM1 1 GALNT7 1 SLC9A3R1 1 DDX60 1 ANKRD20A8P 1 SLC9A3 1 DIO1 1 AP3M2 1 CPSF1 1 ZNF208 1 ANKRD30BL 1 TUBB4A 1 EVI5 1 KIAA0907 1 PKMYT1 1 TNKS1BP1 1 CEP57L1 1 CES3 1 IMP3 1 TRIML1 1 FAM213A 1 C17orf74 1 JAG2 1 GLUL 1 MYO1B 1 HNF1A 1 RALGAPA1 1 AK8 1 SLC7A7 1 FAM24B 1 PPARA 1 SLC26A5 1 TIMELESS 1 CCDC163P 1 ADRA2A 1 KCNN2 1 IDO2 1 RRP1B 1 LIG4 1 PNMA2 1 TG 1 CCNL1 1 SLC10A7 1 C1orf86 1 DRAXIN 1 PGD 1 LBX2 1 PRDX1 1 IRGM 1 ATP6V0A2 1 ANXA13 1 CLIP1 1 TCEA1 1 TTI2 1 RNF151 1 SPAST 1 FKBP14 1 ZNF787 1 OR7G3 1 CENPO 1 MED12L 1 DCUN1D3 1 DNHD1 1 FOXN3 1 RNF128 1 IARS2 1 SSPO 1 PTH2R 1 PCDH19 1 OSBPL6 1 ATP4A 1 ATP5SL 1 COPS6 1 SCAF8 1 UGT2A3 1 UNC5CL 1 HTR2C 1 ZFP3 1 SEL1L 1 LINC00959 1 GTF2IRD2P1 1 SLC2A11 1 GOLGA8H 1 ZNF337 1 RFX6 1 SLC5A10 1 TEC 1 RELB 1 SURF2 1 TMEM236 1 AKAP4 1 MTHFD1 1 MRPS5 1 RPSAP58 1 TPRA1 1 NCEH1 1 KCNA2 1 PTCRA 1 IER3 1 GCFC2 1 ABCA4 1 TOMM34 1 ZCCHC10 1 KRT15 1 GPATCH2L 1 HOXA4 1 SLC29A3 1 BVES 1 UBXN6 1 COX15 1 NUTM2G 1 ABCF1 1 SLC12A6 1 PXN 1 HNRNPF 1 PDHX 1 RGS18 1 CTDSPL 1 TPCN2 1 PDZK1IP1 1 SLURP1 1 MBD6 1 AMN 1 OR1G1 1 MT1G 1 FAM73B 1
Check if FBP1 in mutations¶
In [4]:
[g for g in sorted_genes_w_mutations if g == 'FBP1'] # Not in if it is empty
Out[4]:
[]
Plot the number of mutations and distribution¶
In [5]:
mutations_c = []
for gene in cases_w_mutations:
mutations_c.append(len(cases_w_mutations[gene]))
import matplotlib.pyplot as plt
plt.hist(mutations_c, bins=100)
plt.title('Number of cases with a given mutation')
Out[5]:
Text(0.5, 1.0, 'Number of cases with a given mutation')
In [6]:
case_to_mutation = {}
for gene in cases_w_mutations:
if len(cases_w_mutations[gene]) > 10:
for c in cases_w_mutations[gene]:
if case_to_mutation.get(c):
case_to_mutation[c].append(gene)
else:
case_to_mutation[c] = [gene]
# Check how many patients only have one mutation
number_mutations = []
for c in case_to_mutation:
number_mutations.append(len(case_to_mutation[c]))
# plt.hist(number_mutations, bins=20)
# plt.title("Number of mutations per case (if gene has 5 or more cases)")
Get cases with specific mutations only¶
In [7]:
for c in case_to_mutation:
if len(case_to_mutation[c]) == 1:
print(case_to_mutation[c])
['PBRM1'] ['PBRM1'] ['PBRM1'] ['PBRM1'] ['PBRM1'] ['TTN'] ['TTN'] ['MUC16'] ['MUC16'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['VHL'] ['BAP1'] ['CSMD3']
Visualise the mutation DFs¶
In [8]:
import numpy as np
# We need to read in the RNAseq dataframe (we read in the normalised counts Dataframe)
rna_df = pd.read_csv(f'{output_dir}CCRCC_Clark_Cell2019_rna_filtered_df.csv')
for c in rna_df.columns:
if 'CPT' in c:
rna_df[c] = np.log2(rna_df[c].values + 1)
gene_name = 'external_gene_name'
def plt_top_genes(rna_df, muts, cases_wo_muts, label='', gender='', n_genes=20):
cols = [gene_name]
for c in muts:
for cd in rna_df.columns:
if 'CPTAC' in cd and cd.split('_')[-2] == c:
cols.append(cd)
break
c_i = 0
for c in cases_wo_muts:
for cd in rna_df.columns:
if 'CPTAC' in cd and cd.split('_')[-2] == c and 'PrimaryTumor' in cd:
cols.append(cd)
c_i += 1
break
if c_i == len(muts):
break
cond_df = rna_df[cols].copy()
values = cond_df[cols[1:]]
var_vals = np.var(values, axis=1)
cond_df['Variance'] = var_vals
ko = cols[1:len(muts) + 1]
wt = cols[len(muts) + 1:len(cond_df.columns)]
change_v = np.mean(cond_df[ko].values, axis=1) - np.mean(cond_df[wt].values, axis=1)
cond_df['mean_c'] = change_v
col_colours = [len(wt) * ['r'] + len(ko) * ['b']]
var_b = cond_df.nlargest(n_genes, 'mean_c')
heatmap = Heatmap(var_b, cols[1:], gene_name, f'Largest genes {label}', '', col_colours=col_colours, label_font_size=12, figsize=(6, 5), linewidths=0.5, x_tick_labels=0, cluster_cols=False)
heatmap.plot()
plt.show()
var_b = cond_df.nsmallest(n_genes, 'mean_c')
heatmap = Heatmap(var_b, cols[1:], gene_name, f'Largest genes {label}', '', col_colours=col_colours, label_font_size=12, figsize=(6, 5), linewidths=0.5, x_tick_labels=0, cluster_cols=False)
heatmap.plot()
plt.show()
In [9]:
import numpy as np
genes_of_interest = ['MTOR', 'VHL', 'SETD2', 'PBRM1', 'KDM5C', 'TTN', 'BAP1']
mutations_to_cases = {}
all_cases_w_muts = []
for g in genes_of_interest:
mutations_to_cases[g] = api.get_mutation_values_on_filter('case_id', [g], filter_col, exact=True)
all_cases_w_muts += mutations_to_cases[g]
# Keep track of the cases without mutations
all_cases = clin_df[case_id].values
cases_wo_muts = [c for c in all_cases if c not in all_cases_w_muts]
In [11]:
from sciviso import Heatmap
genes_of_interest = ['VHL', 'PBRM1', 'BAP1']
for g in genes_of_interest:
plt_top_genes(rna_df, mutations_to_cases[g], cases_wo_muts, label=g, gender='', n_genes=20)
In [21]:
## Finally let's add a column to our clinical DF for each of the mutations
genes_of_interest = ['MTOR', 'VHL', 'SETD2', 'PBRM1', 'KDM5C', 'TTN', 'BAP1']
for g in genes_of_interest:
mutation_col = []
for case in clin_mod_df[case_id].values:
if case in mutations_to_cases[g]:
mutation_col.append(1) # has mutation
else:
mutation_col.append(0)
clin_mod_df[f'{g}_mutation'] = mutation_col
In [23]:
# Check if BAP1 or PBMR1 occur at the same time
[c for c, v in case_to_mutation.items() if 'PBRM1' in v and 'BAP1' in v]
Out[23]:
[]
Add molecular classes as well¶
In [25]:
mol_class_df = pd.read_csv(f'{data_dir}CIMP-status_Chr-stability_supp-download.csv')
cimp_pos = mol_class_df[mol_class_df['CIMP status'] == 'CIMP+']['Case ID'].values
unstable = mol_class_df[mol_class_df['Genome instability'] != 'Stable']['Case ID'].values
cimp_values = []
stability_values = []
for case in clin_mod_df[case_id].values:
if case in cimp_pos:
cimp_values.append(1) # Is CIMP pos
else:
cimp_values.append(0)
# Check stability
if case in unstable:
stability_values.append(1)
else:
stability_values.append(0)
clin_mod_df['CIMPStatus'] = cimp_values
clin_mod_df['GenomeInstability'] = stability_values
# Make R friendly cases (they don't like -)
clin_mod_df['SafeCases'] = [c.replace('-', '.') for c in clin_mod_df['case_id'].values]
clin_mod_df.set_index('SafeCases', inplace=True)
In [26]:
clin_mod_df.to_csv(f'{output_dir}clinical_sircle_13052022.csv')
Create groupings of patients¶
We're interested in how having groups of patients with the following 5 mutation "patterns":
1) VHL+TTN
2) VHL-TTN
3) VHL+PBRM1
4) VHL-PBRM1
5) PBRM1-VHL
In [27]:
vhl_and_ttn = [c for c, v in case_to_mutation.items() if 'VHL' in v and 'TTN' in v]
vhl_no_ttn = [c for c, v in case_to_mutation.items() if 'VHL' in v and 'TTN' not in v]
vhl_and_pbrm1 = [c for c, v in case_to_mutation.items() if 'VHL' in v and 'PBRM1' in v]
vhl_no_pbrm1 = [c for c, v in case_to_mutation.items() if 'VHL' in v and 'PBRM1' not in v]
pbrm1_no_vhl = [c for c, v in case_to_mutation.items() if 'VHL' not in v and 'PBRM1' in v]
vhl = [c for c, v in case_to_mutation.items() if 'VHL' in v and 'PBRM1' not in v and 'TTN' not in v]
ttn_no_vhl = [c for c, v in case_to_mutation.items() if 'VHL' not in v and 'TTN' in v]
vhl_ttn_pbrm1 = [c for c, v in case_to_mutation.items() if 'VHL' not in v and 'TTN' in v and 'PBRM1' in v]
pbrm1 = [c for c, v in case_to_mutation.items() if 'PBRM1' in v]
bap1 = [c for c, v in case_to_mutation.items() if 'BAP1' in v]
In [28]:
def add_lbl(case_lst, label_name, df):
cases = [1 if case in case_lst else 0 for case in df['case_id'].values]
df[label_name] = cases
return df
In [32]:
clin_comb = add_lbl(vhl_and_ttn, 'VHL+TTN', clin_mod_df)
clin_comb = add_lbl(vhl_no_ttn, 'VHL-TTN', clin_comb)
clin_comb = add_lbl(vhl_and_pbrm1, 'VHL+PBRM1', clin_comb)
clin_comb = add_lbl(vhl_no_pbrm1, 'VHL-PBRM1', clin_comb)
clin_comb = add_lbl(pbrm1_no_vhl, 'PBRM1-VHL', clin_comb)
clin_comb = add_lbl(vhl, 'VHL', clin_comb)
clin_comb = add_lbl(ttn_no_vhl, 'TTN-VHL', clin_comb)
clin_comb = add_lbl(vhl_ttn_pbrm1, 'TTN+PBRM1-VHL', clin_comb)
clin_comb = add_lbl(bap1, 'BAP1_mutation', clin_comb)
clin_mod_df = clin_comb # Easier for lower down
In [30]:
clin_comb.to_csv(f'{output_dir}clinical_sircle.csv', index=False)
In [33]:
clin_comb
Out[33]:
| case_id | gender | TumorStage | AgeGrouped | BMIGrouped | RaceGrouped | MTOR_mutation | VHL_mutation | SETD2_mutation | PBRM1_mutation | ... | CIMPStatus | GenomeInstability | VHL+TTN | VHL-TTN | VHL+PBRM1 | VHL-PBRM1 | PBRM1-VHL | VHL | TTN-VHL | TTN+PBRM1-VHL | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SafeCases | |||||||||||||||||||||
| C3L.00004 | C3L-00004 | Male | Stage III | old | normal | White | 0 | 1 | 1 | 1 | ... | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| C3L.00010 | C3L-00010 | Male | Stage I | young | between | White | 0 | 1 | 0 | 0 | ... | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 |
| C3L.00011 | C3L-00011 | Female | Stage IV | old | between | White | 0 | 1 | 0 | 0 | ... | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| C3L.00026 | C3L-00026 | Female | Stage I | old | between | White | 0 | 1 | 0 | 0 | ... | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| C3L.00079 | C3L-00079 | Male | Stage III | middle | obese | White | 0 | 1 | 0 | 0 | ... | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 |
| ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... |
| C3N.01646 | C3N-01646 | Male | Stage III | old | between | White | 0 | 0 | 0 | 0 | ... | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| C3N.01648 | C3N-01648 | Male | Stage II | old | between | White | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| C3N.01649 | C3N-01649 | Male | Stage III | middle | obese | White | 0 | 1 | 0 | 1 | ... | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| C3N.01651 | C3N-01651 | Male | Stage II | old | between | White | 0 | 1 | 1 | 1 | ... | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| C3N.01808 | C3N-01808 | Male | Stage I | middle | between | White | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
110 rows × 23 columns
Adding numbers for Alluvial plot¶
Here we want to add the numbers to be able to understand how the patients flow through the alluvial plot.
In [34]:
import pandas as pd
# Stages are stage 1 or other stages
# Want to go through all the mutations (i.e. select the rows with 1 in that column)
ages = ['young' ,'middle', 'old']
cimps = [1, 0]
mutations = [c for c in clin_mod_df.columns if 'mutation' in c]
mutations
Out[34]:
['MTOR_mutation', 'VHL_mutation', 'SETD2_mutation', 'PBRM1_mutation', 'KDM5C_mutation', 'TTN_mutation', 'BAP1_mutation']
In [35]:
import matplotlib.pyplot as plt
mutations = ['VHL_mutation',
'PBRM1_mutation',
'TTN_mutation',
'KDM5C_mutation',
'MTOR_mutation',
'BAP1_mutation',
'SETD2_mutation']
clin_alluvial_df = pd.DataFrame()
cimps = []
for c in clin_mod_df['CIMPStatus'].values:
if c == 1:
cimps.append('+')
else:
cimps.append('-')
clin_alluvial_df['Stage'] = clin_mod_df['TumorStage'].values
clin_alluvial_df['Age'] = clin_mod_df['AgeGrouped'].values
clin_alluvial_df['CIMP'] = cimps
clin_alluvial_df['BMI'] = clin_mod_df['BMIGrouped'].values
clin_alluvial_df['Race'] = clin_mod_df['RaceGrouped'].values
for m in mutations:
mod = []
for c in clin_mod_df[m].values:
if c == 1:
mod.append('Y')
else:
mod.append('N')
clin_alluvial_df[m.split('_')[0]] = mod
case_mutation_count = []
for c in clin_mod_df['case_id'].values:
case_count = 0
for gene, cases in cases_w_mutations.items():
if c in cases:
case_count += 1
case_mutation_count.append(case_count)
plt.hist(case_mutation_count)
Out[35]:
(array([ 3., 8., 8., 24., 20., 21., 12., 9., 2., 3.]),
array([ 0. , 16.3, 32.6, 48.9, 65.2, 81.5, 97.8, 114.1, 130.4,
146.7, 163. ]),
<BarContainer object of 10 artists>)
In [36]:
mutations_simple = []
for m in case_mutation_count:
if m < 20:
mutations_simple.append('<20')
elif m < 40:
mutations_simple.append('20-40')
elif m < 60:
mutations_simple.append('40-60')
elif m < 80:
mutations_simple.append('60-80')
elif m < 100:
mutations_simple.append('80-100')
elif m < 120:
mutations_simple.append('100-120')
else:
mutations_simple.append('>120')
clin_alluvial_df['Mutation count'] = mutations_simple
In [37]:
cols = ['TumorStage', 'AgeGrouped', 'CIMPStatus'] + mutations
cols = list(clin_alluvial_df.columns)
alluvial_2 = clin_alluvial_df.groupby(['Stage', 'Age', 'CIMP', 'VHL', 'PBRM1', 'TTN',
'SETD2', 'BAP1', 'MTOR', 'KDM5C', 'Mutation count'],as_index=False).size()# clin_mod_df.groupby(cols,as_index=False).size()
In [38]:
alluvial_2.to_csv(f'{output_dir}alluvial_age_cimp_stage_mutations-grouped.csv', index=False)